EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice.
ジャーナル・号・ページ	Nat Struct Mol Biol, Year 2024
掲載日	2024年9月6日
著者	Martin Obr / Mathias Percipalle / Darya Chernikova / Huixin Yang / Andreas Thader / Gergely Pinke / Dario Porley / Louis M Mansky / Robert A Dick / Florian K M Schur /
PubMed 要旨	Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we report the results of cryo-electron ...Human T cell leukemia virus type 1 (HTLV-1) immature particles differ in morphology from other retroviruses, suggesting a distinct way of assembly. Here we report the results of cryo-electron tomography studies of HTLV-1 virus-like particles assembled in vitro, as well as derived from cells. This work shows that HTLV-1 uses a distinct mechanism of Gag-Gag interactions to form the immature viral lattice. Analysis of high-resolution structural information from immature capsid (CA) tubular arrays reveals that the primary stabilizing component in HTLV-1 is the N-terminal domain of CA. Mutagenesis analysis supports this observation. This distinguishes HTLV-1 from other retroviruses, in which the stabilization is provided primarily by the C-terminal domain of CA. These results provide structural details of the quaternary arrangement of Gag for an immature deltaretrovirus and this helps explain why HTLV-1 particles are morphologically distinct.
リンク	Nat Struct Mol Biol / PubMed:39242978
手法	EM (サブトモグラム平均) / EM (トモグラフィー)
解像度	3.4 - 6.9 Å
構造データ	17929 8pu6 EMDB-17929, PDB-8pu6: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: pooled class 手法: EM (サブトモグラム平均) / 解像度: 3.4 Å 17930 8pu7 EMDB-17930, PDB-8pu7: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -20 degrees 手法: EM (サブトモグラム平均) / 解像度: 4.8 Å 17931 8pu8 EMDB-17931, PDB-8pu8: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -15 degrees 手法: EM (サブトモグラム平均) / 解像度: 4.0 Å 17932 8pu9 EMDB-17932, PDB-8pu9: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -10 degrees 手法: EM (サブトモグラム平均) / 解像度: 3.7 Å 17933 8pua EMDB-17933, PDB-8pua: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle -05 degrees 手法: EM (サブトモグラム平均) / 解像度: 3.7 Å 17934 8pub EMDB-17934, PDB-8pub: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 0 degrees 手法: EM (サブトモグラム平均) / 解像度: 4.0 Å 17935 8puc EMDB-17935, PDB-8puc: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 05 degrees 手法: EM (サブトモグラム平均) / 解像度: 4.3 Å 17936 8pud EMDB-17936, PDB-8pud: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 10 degrees 手法: EM (サブトモグラム平均) / 解像度: 4.5 Å 17937 8pue EMDB-17937, PDB-8pue: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 15 degrees 手法: EM (サブトモグラム平均) / 解像度: 6.9 Å EMDB-17938: Cryo-electron tomogram of HTLV-1 MA126CANC tubes 手法: EM (トモグラフィー) EMDB-17939: Cryo-electron tomogram of HTLV-1 MA126CANC tubes 手法: EM (トモグラフィー) 17940 8puf EMDB-17940, PDB-8puf: Structure of immature HTLV-1 CA-NTD from in vitro assembled MA126-CANC tubes: axis angle 20 degrees 手法: EM (サブトモグラム平均) / 解像度: 6.1 Å EMDB-17941: Cryo-electron tomogram containing HTLV-1 Gag-based VLPs 手法: EM (トモグラフィー) 17942 8pug EMDB-17942, PDB-8pug: Structure of the immature HTLV-1 CA lattice from full-length Gag VLPs: CA-NTD refinement 手法: EM (サブトモグラム平均) / 解像度: 5.9 Å 17943 8puh EMDB-17943, PDB-8puh: Structure of the immature HTLV-1 CA lattice from full-length Gag VLPs: CA-CTD refinement 手法: EM (サブトモグラム平均) / 解像度: 6.2 Å
由来	human t-cell leukemia virus type i (ウイルス)
キーワード	VIRAL PROTEIN / Retrovirus / HTLV / immature capsid / CA / CA-NTD