タイトル | Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. |
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ジャーナル・号・ページ | Rsc Med Chem, Vol. 14, Page 921-933, Year 2023 |
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掲載日 | 2023年3月13日 (構造データの登録日) |
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著者 | Pathirage, R. / Favrot, L. / Petit, C. / Yamsek, M. / Singh, S. / Mallareddy, J.R. / Rana, S. / Natarajan, A. / Ronning, D.R. |
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リンク | Rsc Med Chem / PubMed:37252106 |
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手法 | X線回折 |
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解像度 | 1.81 - 3.3 Å |
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構造データ | PDB-8gi7: C143A variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 3.3 Å PDB-8giw: C143K variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 3.15 Å PDB-8glb: Selenomethionine Derivatized Citrate Synthase (CitA) in Mycobacterium tuberculosis with Pyruvate 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-8gll: R149E variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-8gm9: Structure of Citrate Synthase(CitA) in Mycobacterium Tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8gmf: R153M variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 2.96 Å PDB-8gmi: Citrate Synthase (CitA) in Mycobacterium tuberculosis modified by Ebselen at C143 residue 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-8gmk: Pyruvate bound structure of Citrate Synthase (CitA) in Mycobacterium Tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-8s97: C143W variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-8s9d: C143S variant of Citrate Synthase (CitA) in Mycobacterium tuberculosis 手法: X-RAY DIFFRACTION / 解像度: 2.57 Å |
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化合物 | |
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由来 | - mycobacterium tuberculosis h37rv (結核菌)
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キーワード | CYTOSOLIC PROTEIN / Citrate Synthesis / TCA cycle / C143A variant / C143K variant / Pyruvate / R149E variant / R153M variant / cysteine modified by Ebselen / C143W variant / C143S variant |
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