EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
ジャーナル・号・ページ	J. Med. Chem., Vol. 66, Page 934-950, Year 2023
掲載日	2022年5月22日 (構造データの登録日)
著者	Zhou, J. / Horton, J.R. / Menna, M. / Fiorentino, F. / Ren, R. / Yu, D. / Hajian, T. / Vedadi, M. / Mazzoccanti, G. / Ciogli, A. ...Zhou, J. / Horton, J.R. / Menna, M. / Fiorentino, F. / Ren, R. / Yu, D. / Hajian, T. / Vedadi, M. / Mazzoccanti, G. / Ciogli, A. / Weinhold, E. / Huben, M. / Blumenthal, R.M. / Zhang, X. / Mai, A. / Rotili, D. / Cheng, X.
リンク	J. Med. Chem. / PubMed:36581322
手法	X線回折
解像度	2.19 - 2.81 Å
構造データ	PDB-8cxs: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor MTA 手法: X-RAY DIFFRACTION / 解像度: 2.49 Å PDB-8cxt: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-benzyladenosine (Compound 1) 手法: X-RAY DIFFRACTION / 解像度: 2.61 Å PDB-8cxu: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 2 手法: X-RAY DIFFRACTION / 解像度: 2.28 Å PDB-8cxv: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 3 手法: X-RAY DIFFRACTION / 解像度: 2.26 Å PDB-8cxw: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor piclidenoson (Compound 4) 手法: X-RAY DIFFRACTION / 解像度: 2.78 Å PDB-8cxx: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 6 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-8cxy: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-(2-Phenethyl)adenosine (Compound 8) 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-8cxz: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor N6-(3-Phenylpropyl)adenosine (Compound 14) 手法: X-RAY DIFFRACTION / 解像度: 2.35 Å PDB-8cy0: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor MC4756 (Compound 178) 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-8cy1: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 19 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-8cy2: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor APNEA (Compound 9) 手法: X-RAY DIFFRACTION / 解像度: 2.81 Å PDB-8cy3: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 15 手法: X-RAY DIFFRACTION / 解像度: 2.65 Å PDB-8cy4: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 16 手法: X-RAY DIFFRACTION / 解像度: 2.34 Å PDB-8cy5: CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Compound 39 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å
化合物	ChemComp-K: Unknown entry / カリウムカチオン ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-MTA: 5'-DEOXY-5'-METHYLTHIOADENOSINE / メチルチオアデノシン ChemComp-HOH: WATER ChemComp-Q8C: N-benzyladenosine / N-ベンジルアデノシン ChemComp-T96: N-[(4-aminophenyl)methyl]adenosine / N-(4-アミノベンジル)アデノシン ChemComp-T9R: N-[(4-hydroxyphenyl)methyl]adenosine / p-トポリンリボシド ChemComp-Q8L: Piclidenoson / IB-MECA ChemComp-T9I: N-[(1R)-2,3-dihydro-1H-inden-1-yl]adenosine / CI-947 ChemComp-Q8R: N-(2-phenylethyl)adenosine / N-(2-フェニルエチル)アデノシン ChemComp-Q8Y: N-(3-phenylpropyl)adenosine / N-(3-フェニルプロピル)アデノシン ChemComp-Q9W: N-(4-phenylbutyl)adenosine / N-(4-フェニルブチル)アデノシン ChemComp-QBU: N-(5-phenylpentyl)adenosine ChemComp-QA2: N-[2-(4-aminophenyl)ethyl]adenosine / APNEA ChemComp-TAI: N-[3-(4-aminophenyl)propyl]adenosine ChemComp-QA6: N-[3-(4-hydroxyphenyl)propyl]adenosine ChemComp-T8Q: N-{3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propyl}adenosine
由来	clostridioides difficile (バクテリア) clostridioides difficile 630 (バクテリア)
キーワード	DNA BINDING PROTEIN/DNA / DNA Adenine Methylation / PROTEIN-DNA COMPLEX / TRANSFERASE / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex