EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural basis of FPR2 in recognition of Aβ and neuroprotection by humanin.
ジャーナル・号・ページ	Nat Commun, Vol. 13, Issue 1, Page 1775, Year 2022
掲載日	2022年4月1日
著者	Ya Zhu / Xiaowen Lin / Xin Zong / Shuo Han / Mu Wang / Yuxuan Su / Limin Ma / Xiaojing Chu / Cuiying Yi / Qiang Zhao / Beili Wu /
PubMed 要旨	Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the β amyloid peptide Aβ and serves as a receptor for humanin, a peptide that protects neuronal cells from damage ...Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the β amyloid peptide Aβ and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by Aβ, implying its involvement in the pathogenesis of Alzheimer's disease (AD). However, the interaction pattern between FPR2 and Aβ or humanin remains unknown. Here we report the structures of FPR2 bound to G and Aβ or N-formyl humanin (fHN). Combined with functional data, the structures reveal two critical regions that govern recognition and activity of Aβ and fHN, including a polar binding cavity within the receptor helical bundle and a hydrophobic binding groove in the extracellular region. In addition, the structures of FPR2 and FPR1 in complex with different formyl peptides were determined, providing insights into ligand recognition and selectivity of the FPR family. These findings uncover key factors that define the functionality of FPR2 in AD and other inflammatory diseases and would enable drug development.
リンク	Nat Commun / PubMed:35365641 / PubMed Central
手法	EM (単粒子)
解像度	2.8 - 3.3 Å
構造データ	32858 7wvu EMDB-32858, PDB-7wvu: Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 手法: EM (単粒子) / 解像度: 3.3 Å 32859 7wvv EMDB-32859, PDB-7wvv: Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 手法: EM (単粒子) / 解像度: 2.9 Å 32860 7wvw EMDB-32860, PDB-7wvw: Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 手法: EM (単粒子) / 解像度: 3.1 Å 32861 7wvx EMDB-32861, PDB-7wvx: Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 手法: EM (単粒子) / 解像度: 2.8 Å 32862 7wvy EMDB-32862, PDB-7wvy: Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 手法: EM (単粒子) / 解像度: 3.0 Å
由来	homo sapiens (ヒト)
キーワード	SIGNALING PROTEIN / G protein-coupled receptor (Gタンパク質共役受容体) / formyl peptide receptor / FPR1 / fMLF / FPR2 / fMLFII / fMYFINILTL / humanin (ヒューマニン) / Abeta42