タイトル | Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1 |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2020年6月28日 (構造データの登録日) |
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著者 | Liu YX / Sun M / Myasnikov AG / Elnatan D / Agard DA |
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リンク | PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.71 - 3.8 Å |
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構造データ | EMDB-22240, PDB-6xld: Full-length Hsc82 in complex with Aha1 CTD in the presence of AMPPNP 手法: EM (単粒子) / 解像度: 3.66 Å EMDB-22241, PDB-6xle: Full-length Hsc82 in complex with two Aha1 CTD in the presence of AMP-PNP 手法: EM (単粒子) / 解像度: 2.74 Å EMDB-22242, PDB-6xlf: Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP 手法: EM (単粒子) / 解像度: 3.15 Å EMDB-22243, PDB-6xlg: Full-length Hsc82 in complex with two Aha1 CTD in the presence of ATPgammaS 手法: EM (単粒子) / 解像度: 2.71 Å EMDB-22244, PDB-6xlh: Asymmetric hydrolysis state of Hsc82 in complex with Aha1 bound with ADP and ATPgammaS 手法: EM (単粒子) / 解像度: 2.83 Å |
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化合物 | ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体*YM
ChemComp-AGS: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER / ATP-γ-S / ATP-gamma-S, エネルギー貯蔵分子類似体*YM
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由来 | ![](img/tx_yeast.gif) saccharomyces cerevisiae (strain atcc 204508 / s288c) (パン酵母)
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キーワード | CHAPERONE / Co-chaperone / activator / Hsp90 |
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