タイトル | Cyclic peptides can engage a single binding pocket through highly divergent modes. |
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ジャーナル・号・ページ | Proc. Natl. Acad. Sci. USA, Vol. 117, Page 26728-26738, Year 2020 |
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掲載日 | 2019年8月24日 (構造データの登録日) |
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著者 | Patel, K. / Walport, L.J. / Walshe, J.L. / Solomon, P.D. / Low, J.K.K. / Tran, D.H. / Mouradian, K.S. / Silva, A.P.G. / Wilkinson-White, L. / Norman, A. ...Patel, K. / Walport, L.J. / Walshe, J.L. / Solomon, P.D. / Low, J.K.K. / Tran, D.H. / Mouradian, K.S. / Silva, A.P.G. / Wilkinson-White, L. / Norman, A. / Franck, C. / Matthews, J.M. / Guss, J.M. / Payne, R.J. / Passioura, T. / Suga, H. / Mackay, J.P. |
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リンク | Proc. Natl. Acad. Sci. USA / PubMed:33046654 |
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手法 | X線回折 |
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解像度 | 1.47 - 2.8 Å |
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構造データ | PDB-6u4a: BRD3-BD1 in complex with the cyclic peptide 3.1_3 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6u61: BRD2-BD1 in complex with the cyclic peptide 3.1_3 手法: X-RAY DIFFRACTION / 解像度: 2.29 Å PDB-6u6k: BRD4-BD1 in complex with the cyclic peptide 3.1_3 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6u6l: BRD4-BD2 in complex with the cyclic peptide 3.1_2 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6u71: BRD2-BD2 in complex with the cyclic peptide 3.1_3 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-6u72: BRD4-BD1 in complex with the cyclic peptide 3.1_2_AcK5toA 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6u74: BRD4-BD1 in complex with the cyclic peptide 3.1_2 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6u8g: BRD4-BD2 in complex with the cyclic peptide 3.1_2_AcK7toA 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-6u8h: BRD2-BD1 in complex with the cyclic peptide 3.2_2 手法: X-RAY DIFFRACTION / 解像度: 2.07 Å PDB-6u8i: BRD4-BD2 in complex with the cyclic peptide 3.2_2 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-6u8m: BRD4-BD1 in complex with the cyclic peptide 3.2_1 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6ulp: BRD3-BD2 in complex with the cyclic peptide 3.2_3 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-6ulq: BRD2-BD1 in complex with the cyclic peptide 4.2_3 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6ult: BRD2-BD2 in complex with the cyclic peptide 4.2_3 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-6ulv: BRD4-BD1 in complex with the cyclic peptide 4.2_1 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å |
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化合物 | ChemComp-PE3: 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL / 3,6,9,12,15,18,21,24,27,30,33,36,39-トリデカオキサヘンテトラコンタン-1,41-ジ(以下略)
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由来 | homo sapiens (ヒト)- synthetic construct (人工物)
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キーワード | Transcription/Inhibitor / BET / bromodomain / macrocyclic peptide / BRD3 / inhibitor / RaPID / Transcription-Inhibitor complex / BRD2 / BRD4 / TRANSCRIPTION |
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