タイトル | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. |
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ジャーナル・号・ページ | Biochim Biophys Acta Proteins Proteom, Vol. 1868, Page 140404-140404, Year 2020 |
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掲載日 | 2010年9月16日 (構造データの登録日) |
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著者 | Palm, G.J. / Buchholz, I. / Werten, S. / Girbardt, B. / Berndt, L. / Delcea, M. / Hinrichs, W. |
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リンク | Biochim Biophys Acta Proteins Proteom / PubMed:32114262 |
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手法 | X線回折 |
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解像度 | 1.602 - 2.1 Å |
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構造データ | PDB-2xrl: Tet-repressor class D T103A with doxycycline 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-4b3a: Tetracycline repressor class D mutant H100A in complex with tetracycline 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-6fpl: TETR(D) E147A MUTANT IN COMPLEX WITH TETRACYCLINE AND MAGNESIUM 手法: X-RAY DIFFRACTION / 解像度: 1.602 Å PDB-6fpm: TetR(D) T103A mutant in complex with tetracycline and magnesium 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6fts: TETR(D) N82A MUTANT IN COMPLEX WITH PEG4 手法: X-RAY DIFFRACTION / 解像度: 2 Å PDB-6qjw: TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6qjx: TetR(D) T103A mutant in complex with minocycline and magnesium 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6rbl: TETR(D) E147A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6rbm: TETR(D) E147A MUTANT IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-6rcr: TETR(D) H100A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-6rgx: TETR(D) N82A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
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化合物 | ChemComp-DXT: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE / ドキシサイクリン / 抗生剤*YM
ChemComp-MIY: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- / ミノサイクリン / 薬剤, 抗生剤*YM
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由来 | - escherichia coli (大腸菌)
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キーワード | TRANSCRIPTION / ANTIBIOTIC RESISTANCE / DNA-BINDING / HELIX-TURN-HELIX / TET-REPRESSOR / TRANSCRIPTION REGULATION |
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