タイトル | Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases. |
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ジャーナル・号・ページ | Acs Chem. Biol., Vol. 15, Page 407-415, Year 2020 |
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掲載日 | 2018年8月20日 (構造データの登録日) |
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著者 | Pang, L. / Nautiyal, M. / De Graef, S. / Gadakh, B. / Zorzini, V. / Economou, A. / Strelkov, S.V. / Van Aerschot, A. / Weeks, S.D. |
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リンク | Acs Chem. Biol. / PubMed:31869198 |
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手法 | X線回折 |
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解像度 | 1.84 - 2.41 Å |
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構造データ | PDB-6hdz: Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine 手法: X-RAY DIFFRACTION / 解像度: 2.06 Å PDB-6he1: Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine 手法: X-RAY DIFFRACTION / 解像度: 2.22 Å PDB-6he3: Pseudomonas aeruginosa Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine 手法: X-RAY DIFFRACTION / 解像度: 2.16 Å PDB-6hhv: Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-6hhw: Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)uridine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6hhx: Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)cytidine 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-6hhy: Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine 手法: X-RAY DIFFRACTION / 解像度: 2.27 Å PDB-6hhz: Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å PDB-6hi0: Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-6rlt: Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-6rlu: Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6rlv: Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6s30: Crystal Structure of Seryl-tRNA Synthetase from Klebsiella pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-6sjc: Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)adenosine 手法: X-RAY DIFFRACTION / 解像度: 2.23 Å |
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化合物 | ChemComp-FZT: 5'-O-(N-(L-seryl)-sulfamoyl)N3-methyluridine
ChemComp-G5Q: 5'-O-(N-(L-aspartyl)-sulfamoyl)N3-methyluridine
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由来 | - pseudomonas aeruginosa (緑膿菌)
- thermus thermophilus (バクテリア)
- klebsiella pneumoniae (肺炎桿菌)
- trypanosoma brucei gambiense (ガンビアトリパノソーマ)
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キーワード | LIGASE / Coil-coil / Beta barrel / tRNA Synthetase / Inhibitor / Complex / protein-inhibitor complex / tRNA aminoacylation |
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