タイトル | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE |
---|
ジャーナル・号・ページ | Sci Rep, Vol. 7, Page 10815-10815, Year 2017 |
---|
掲載日 | 2017年1月18日 (構造データの登録日) |
---|
著者 | Hou, S. / Xu, T. / Xu, J. / Qu, L. / Xu, Y. / Chen, L. / Liu, J. |
---|
リンク | Sci Rep / PubMed:28883454 |
---|
手法 | X線回折 |
---|
解像度 | 1.8 - 2.4 Å |
---|
構造データ | PDB-5wzm: Crystal structure of human secreted phospholipase A2 group IIE 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-5wzo: Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-5wzs: Crystal structure of human secreted phospholipase A2 group IIE with Compound 8 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-5wzt: Crystal structure of human secreted phospholipase A2 group IIE with Compound 14 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-5wzu: Crystal structure of human secreted phospholipase A2 group IIE with Compound 24 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5wzv: Crystal structure of human secreted phospholipase A2 group IIE with Me-indoxam 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-5wzw: Crystal structure of human secreted phospholipase A2 group IIE with LY311727 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-5y5e: Crystal structure of phospholipase A2 with inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å |
---|
化合物 | ChemComp-7W9: 2-[2-methyl-1-(naphthalen-1-ylmethyl)-3-oxamoyl-indol-4-yl]oxyethanoic acid
ChemComp-7W6: 2-[1-[(3-bromophenyl)methyl]-2-methyl-3-oxamoyl-indol-4-yl]oxyethanoic acid
ChemComp-7W3: 2-[2-methyl-3-oxamoyl-1-[[2-(trifluoromethyl)phenyl]methyl]indol-4-yl]oxyethanoic acid
ChemComp-U8D: (3-{[3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid / LY-311727
|
---|
由来 | homo sapiens (ヒト)
|
---|
キーワード | HYDROLASE/INHIBITOR / inhibitor / HYDROLASE-INHIBITOR complex / phospholipase A2 / mutant |
---|