EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
ジャーナル・号・ページ	J. Med. Chem., Vol. 56, Page 660-, Year 2013
掲載日	2012年10月2日 (構造データの登録日)
著者	Hole, A.J. / Baumli, S. / Shao, H. / Shi, S. / Pepper, C. / Fischer, P.M. / Wang, S. / Endicott, J.A. / Noble, M.E.M.
リンク	J. Med. Chem. / PubMed:23252711
手法	X線回折
解像度	2.05 - 3.162 Å
構造データ	PDB-4bcf: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.011 Å PDB-4bch: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.958 Å PDB-4bci: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-4bcj: Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 3.162 Å PDB-4bck: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.052 Å PDB-4bcm: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-4bcn: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å PDB-4bco: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-4bcq: Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å
化合物	ChemComp-T6Q: 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile ChemComp-HOH: WATER ChemComp-T7Z: 4-(4-methyl-2-methylimino-3H-1,3-thiazol-5-yl)-2-[(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)amino]pyrimidine-5-carbonitrile ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-T3E: 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide ChemComp-T9N: 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile ChemComp-SGM: MONOTHIOGLYCEROL / (2R)-3-メルカプト-1,2-プロパンジオ-ル ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-TJF: 4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile
由来	homo sapiens (ヒト) bos taurus (ウシ)
キーワード	TRANSFERASE/CELL CYCLE / TRANSFERASE-CELL CYCLE COMPLEX / CDK-CYCLIN COMPLEX / TRANSCRIPTION-PROTEIN BINDING / STRUCTURE-BASED DRUG DESIGN / CYCLIN-INHIBITOR / CYCLIN A / CYCLIN- DEPENDENT KINASE 2