タイトル | Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae |
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ジャーナル・号・ページ | Antimicrob. Agents Chemother., Vol. 52, Page 2053-2060, Year 2008 |
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掲載日 | 2007年11月2日 (構造データの登録日) |
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著者 | Yamada, M. / Watanabe, T. / Baba, N. / Takeuchi, Y. / Ohsawa, F. / Gomi, S. |
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リンク | Antimicrob. Agents Chemother. / PubMed:18391040 |
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手法 | X線回折 |
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解像度 | 2.5 - 3 Å |
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構造データ | PDB-2zc3: Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å PDB-2zc4: Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2zc5: Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-2zc6: Penicillin-binding protein 1A (PBP 1A) acyl-enzyme complex (tebipenem) from Streptococcus pneumoniae 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å |
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化合物 | ChemComp-BMG: (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth
ChemComp-TEB: (4R,5S)-3-(1-(4,5-dihydrothiazol-2-yl)azetidin-3-ylthio)-5-((2S,3R)-3-hydroxy-1-oxobutan-2-yl)-4-methyl-4,5- dihydro-1H-pyrrole-2-carboxylic acid
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由来 | ![](img/tx_bacteria.gif) streptococcus pneumoniae (肺炎レンサ球菌)
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キーワード | BIOSYNTHETIC PROTEIN / PEPTIDOGLYCAN SYNTHESIS / CELL WALL / PENICILLIN-BINDING / ANTIBIOTICS / BIAPENEM / Antibiotic resistance / Cell cycle / Cell division / Cell shape / Cell wall biogenesis/degradation / Membrane / Secreted / Transmembrane / TEBIPENEM / Multifunctional enzyme |
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