タイトル | Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3). |
---|
ジャーナル・号・ページ | Structure, Vol. 16, Page 873-884, Year 2008 |
---|
掲載日 | 2007年7月19日 (構造データの登録日) |
---|
著者 | Davis, T.L. / Walker, J.R. / Loppnau, P. / Butler-Cole, C. / Allali-Hassani, A. / Dhe-Paganon, S. |
---|
リンク | Structure / PubMed:18547520 |
---|
手法 | X線回折 |
---|
解像度 | 1.07 - 1.79 Å |
---|
構造データ | PDB-2qo2: Human EphA3 kinase and juxtamembrane region, dephosphorylated, apo structure 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-2qo7: Human EphA3 kinase and juxtamembrane region, dephosphorylated, AMP-PNP bound 手法: X-RAY DIFFRACTION / 解像度: 1.605 Å PDB-2qo9: Human EphA3 kinase and juxtamembrane region, phosphorylated, AMP-PNP bound 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-2qob: Human EphA3 kinase domain, base structure 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-2qoc: Human EphA3 kinase domain, phosphorylated, AMP-PNP bound structure 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-2qod: Human EphA3 kinase and juxtamembrane region, Y602F mutant 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-2qof: Human EphA3 kinase and juxtamembrane region, Y596F mutant 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-2qoi: Human EphA3 kinase and juxtamembrane region, Y596F:Y602F double mutant 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-2qok: Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:S768A triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-2qol: Human EphA3 kinase and juxtamembrane region, Y596:Y602:S768G triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.07 Å PDB-2qon: Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742A triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-2qoo: Human EphA3 kinase and juxtamembrane region, Y596F:Y602F:Y742F triple mutant 手法: X-RAY DIFFRACTION / 解像度: 1.25 Å PDB-2qoq: Human EphA3 kinase and juxtamembrane region, base, AMP-PNP bound structure 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å |
---|
化合物 | ChemComp-ANP: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP / AMP-PNP, エネルギー貯蔵分子類似体*YM
|
---|
由来 | - homo sapiens (ヒト)
|
---|
キーワード | TRANSFERASE / receptor tyrosine kinase / juxtamembrane segment / structural genomics / Structural Genomics Consortium / SGC / ATP-binding / Nucleotide-binding / Phosphorylation / Transmembrane / Tyrosine-protein kinase / AMP-PNP / Membrane / mutants / mutant |
---|