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-Structure paper
タイトル | Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. |
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ジャーナル・号・ページ | Nat Struct Mol Biol, Vol. 25, Issue 2, Page 131-134, Year 2018 |
掲載日 | 2018年1月15日 |
著者 | Marcus Gallagher-Jones / Calina Glynn / David R Boyer / Michael W Martynowycz / Evelyn Hernandez / Jennifer Miao / Chih-Te Zee / Irina V Novikova / Lukasz Goldschmidt / Heather T McFarlane / Gustavo F Helguera / James E Evans / Michael R Sawaya / Duilio Cascio / David S Eisenberg / Tamir Gonen / Jose A Rodriguez / |
PubMed 要旨 | The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution ...The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named 'polar clasps'. |
リンク | Nat Struct Mol Biol / PubMed:29335561 / PubMed Central |
手法 | EM (電子線結晶学) / X線回折 |
解像度 | 0.75 - 1.1 Å |
構造データ | EMDB-7287: PDB-6btk: |
化合物 | ChemComp-HOH: |
由来 |
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キーワード | PROTEIN FIBRIL / polar clasp / amyloid fibril / prion |