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-Structure paper
| タイトル | Cryo-EM structure of single-layered nucleoprotein-RNA complex from Marburg virus. |
|---|---|
| ジャーナル・号・ページ | Nat Commun, Vol. 15, Issue 1, Page 10307, Year 2024 |
| 掲載日 | 2024年11月27日 |
著者 | Luca Zinzula / Florian Beck / Marianna Camasta / Stefan Bohn / Chuan Liu / Dustin Morado / Andreas Bracher / Juergen M Plitzko / Wolfgang Baumeister / ![]() |
| PubMed 要旨 | Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) ...Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease. |
リンク | Nat Commun / PubMed:39604358 / PubMed Central |
| 手法 | EM (らせん対称) / EM (単粒子) |
| 解像度 | 3.1 - 3.2 Å |
| 構造データ | EMDB-50803, PDB-9fvd: ![]() EMDB-50804: Density for a protein trimer unit bound to RNA from a single-layered nucleoprotein-RNA helical assembly from Marburg virus |
| 由来 |
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キーワード | VIRAL PROTEIN / RNA-binding protein |
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Marburg virus - Musoke, Kenya, 1980 (ウイルス)
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