EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics.
ジャーナル・号・ページ	Structure, Vol. 28, Issue 10, Page 1087-11100.e3, Year 2020
掲載日	2020年10月6日
著者	David Nicholson / Thomas A Edwards / Alex J O'Neill / Neil A Ranson /
PubMed 要旨	Acinetobacter baumannii is a Gram-negative bacterium primarily associated with hospital-acquired, often multidrug-resistant (MDR) infections. The ribosome-targeting antibiotics amikacin and ...Acinetobacter baumannii is a Gram-negative bacterium primarily associated with hospital-acquired, often multidrug-resistant (MDR) infections. The ribosome-targeting antibiotics amikacin and tigecycline are among the limited arsenal of drugs available for treatment of such infections. We present high-resolution structures of the 70S ribosome from A. baumannii in complex with these antibiotics, as determined by cryoelectron microscopy. Comparison with the ribosomes of other bacteria reveals several unique structural features at functionally important sites, including around the exit of the polypeptide tunnel and the periphery of the subunit interface. The structures also reveal the mode and site of interaction of these drugs with the ribosome. This work paves the way for the design of new inhibitors of translation to address infections caused by MDR A. baumannii.
リンク	Structure / PubMed:32857965 / PubMed Central
手法	EM (単粒子)
解像度	2.5 - 3.0 Å
構造データ	10809 6yhs EMDB-10809, PDB-6yhs: Acinetobacter baumannii ribosome-amikacin complex - 50S subunit 手法: EM (単粒子) / 解像度: 2.7 Å 10869 6ypu EMDB-10869, PDB-6ypu: Acinetobacter baumannii ribosome-amikacin complex - 30S subunit body 手法: EM (単粒子) / 解像度: 2.9 Å 10892 6ys5 EMDB-10892, PDB-6ys5: Acinetobacter baumannii ribosome-amikacin complex - 30S subunit head 手法: EM (単粒子) / 解像度: 3.0 Å 10898 6ysi EMDB-10898, PDB-6ysi: Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit 手法: EM (単粒子) / 解像度: 2.5 Å 10914 6yt9 EMDB-10914, PDB-6yt9: Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit body 手法: EM (単粒子) / 解像度: 2.7 Å 10915 6ytf EMDB-10915, PDB-6ytf: Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head 手法: EM (単粒子) / 解像度: 3.0 Å
化合物	ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-ZN: Unknown entry ChemComp-AKN: (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S / アミカシン / 薬剤, 抗生剤YM / アミカシン ChemComp-T1C: TIGECYCLINE / 薬剤, 抗生剤YM / Tigecycline
由来	acinetobacter baumannii atcc 19606 = cip 70.34 = jcm 6841 (バクテリア) acinetobacter baumannii (strain atcc 19606 / dsm 30007 / cip 70.34 / jcm 6841 / nbrc 109757 / ncimb 12457 / nctc 12156 / 81) (バクテリア) acinetobacter baumannii (バクテリア)
キーワード	RIBOSOME (リボソーム) / antibiotic (抗生物質) / amikacin (アミカシン) / translation (翻訳 (生物学)) / tigecycline