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Structure paper

TitleStructural and functional evidence that GPR30 is not a direct estrogen receptor.
Journal, issue, pagesCell Res, Vol. 34, Issue 7, Page 530-533, Year 2024
Publish dateMay 14, 2024
AuthorsHeng Liu / Shimeng Guo / Antao Dai / Peiyu Xu / Xin Li / Sijie Huang / Xinheng He / Kai Wu / Xinyue Zhang / Dehua Yang / Xin Xie / H Eric Xu /
External linksCell Res / PubMed:38744981 / PubMed Central
MethodsEM (single particle)
Resolution2.6 - 3.2 Å
Structure data

EMDB-38527, PDB-8xof:
Cryo-EM structure of Lys05 bound GPR30-Gq complex structure
Method: EM (single particle) / Resolution: 2.6 Å

EMDB-38528, PDB-8xog:
Cryo-EM structure of apo-GPR30-Gq complex structure
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-38529, PDB-8xoh:
Cryo-EM structure of GPR30-Gq complex structure in the presence of E2
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-38530, PDB-8xoi:
Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-38531, PDB-8xoj:
Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

PDB-1lvw:
Crystal structure of glucose-1-phosphate thymidylyltransferase, RmlA, complex with dTDP

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
  • synthetic construct (others)
KeywordsMEMBRANE PROTEIN/IMMUNE SYSTEM / GPCR / estrogen / GPR30 / Gq / MEMBRANE PROTEIN / MEMBRANE PROTEIN-IMMUNE SYSTEM complex

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