Entry Database : EMDB / ID : EMD-38527 Downloads & linksTitle Cryo-EM structure of Lys05 bound GPR30-Gq complex structure Map data Details SampleComplex : GPR30-Gq complexComplex : GPR30-GqProtein or peptide : G protein subunit qProtein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Protein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Protein or peptide : G-protein coupled estrogen receptor 1Complex : Nanobody35Protein or peptide : Nanobody35Ligand : Lys01 Details Keywords GPCR / estrogen / GPR30 / Gq / MEMBRANE PROTEIN / MEMBRANE PROTEIN-IMMUNE SYSTEM complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of leukocyte activation / nuclear fragmentation involved in apoptotic nuclear change / positive regulation of cardiac vascular smooth muscle cell differentiation / negative regulation of cell cycle process / positive regulation of inositol trisphosphate biosynthetic process / keratin filament / positive regulation of uterine smooth muscle contraction / negative regulation of lipid biosynthetic process / apoptotic chromosome condensation / steroid hormone binding ... negative regulation of leukocyte activation / nuclear fragmentation involved in apoptotic nuclear change / positive regulation of cardiac vascular smooth muscle cell differentiation / negative regulation of cell cycle process / positive regulation of inositol trisphosphate biosynthetic process / keratin filament / positive regulation of uterine smooth muscle contraction / negative regulation of lipid biosynthetic process / apoptotic chromosome condensation / steroid hormone binding / positive regulation of G protein-coupled receptor signaling pathway / cellular response to mineralocorticoid stimulus / positive regulation of endothelial cell apoptotic process / positive regulation of extrinsic apoptotic signaling pathway / dendritic spine membrane / positive regulation of neurotransmitter secretion / cellular response to peptide hormone stimulus / positive regulation of neurogenesis / positive regulation of epidermal growth factor receptor signaling pathway / G protein-coupled estrogen receptor activity / negative regulation of fat cell differentiation / dendritic spine head / nuclear estrogen receptor activity / presynaptic active zone / negative regulation of vascular associated smooth muscle cell proliferation / positive regulation of release of cytochrome c from mitochondria / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / steroid hormone receptor signaling pathway / neuronal action potential / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / nuclear receptor-mediated steroid hormone signaling pathway / axon terminus / regulation of cytosolic calcium ion concentration / steroid binding / hippocampal mossy fiber to CA3 synapse / Peptide ligand-binding receptors / positive regulation of release of sequestered calcium ion into cytosol / dendritic shaft / cellular response to estradiol stimulus / G protein-coupled receptor activity / mitochondrial membrane / cellular response to glucose stimulus / positive regulation of protein localization to plasma membrane / Olfactory Signaling Pathway / cytoplasmic vesicle membrane / Activation of the phototransduction cascade / trans-Golgi network / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / Thromboxane signalling through TP receptor / adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of insulin secretion / G-protein activation / G protein-coupled acetylcholine receptor signaling pathway / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / recycling endosome / Prostacyclin signalling through prostacyclin receptor / Glucagon signaling in metabolic regulation / G beta:gamma signalling through CDC42 / negative regulation of ERK1 and ERK2 cascade / ADP signalling through P2Y purinoceptor 12 / G beta:gamma signalling through BTK / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Sensory perception of sweet, bitter, and umami (glutamate) taste / photoreceptor disc membrane / negative regulation of inflammatory response / Adrenaline,noradrenaline inhibits insulin secretion / Glucagon-type ligand receptors / Vasopressin regulates renal water homeostasis via Aquaporins / G alpha (z) signalling events / cellular response to catecholamine stimulus / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / ADORA2B mediated anti-inflammatory cytokines production / sensory perception of taste / ADP signalling through P2Y purinoceptor 1 / adenylate cyclase-activating dopamine receptor signaling pathway / vasodilation / G beta:gamma signalling through PI3Kgamma / cellular response to prostaglandin E stimulus / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / GPER1 signaling / G-protein beta-subunit binding / Inactivation, recovery and regulation of the phototransduction cascade / heterotrimeric G-protein complex / G alpha (12/13) signalling events / extracellular vesicle / signaling receptor complex adaptor activity / Thrombin signalling through proteinase activated receptors (PARs) / GTPase binding / retina development in camera-type eye / nuclear envelope / presynaptic membrane / phospholipase C-activating G protein-coupled receptor signaling pathway / Ca2+ pathway / cellular response to tumor necrosis factor / nervous system development / positive regulation of cytosolic calcium ion concentration / G alpha (i) signalling events / fibroblast proliferation Similarity search - Function : / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit ... : / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily Similarity search - Domain/homology Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 / G-protein coupled estrogen receptor 1 Similarity search - ComponentBiological species Homo sapiens (human) / Lama glama (llama)Method single particle reconstruction / cryo EM / Resolution : 2.6 Å Details AuthorsLiu H / Xu P / Xu HE Funding support China, 1 items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) China
CitationJournal : Cell Res / Year : 2024Title : Structural and functional evidence that GPR30 is not a direct estrogen receptor.Authors : Heng Liu / Shimeng Guo / Antao Dai / Peiyu Xu / Xin Li / Sijie Huang / Xinheng He / Kai Wu / Xinyue Zhang / Dehua Yang / Xin Xie / H Eric Xu / History Deposition Jan 1, 2024 - Header (metadata) release Apr 10, 2024 - Map release Apr 10, 2024 - Update Jul 10, 2024 - Current status Jul 10, 2024 Processing site : PDBj / Status : Released
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