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-Structure paper
Title | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation |
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Journal, issue, pages | Elife, Year 2023 |
Publish date | Jun 22, 2023 (structure data deposition date) |
Authors | Frey L / Ghosh D / Qureshi BM / Rhyner D / Pokharna A / Guerrero-Ferreira R / Kwiatkowski W / Serdiuk T / Picotti P / Riek R / Greenwald J |
External links | Elife / Search PubMed |
Methods | EM (helical sym.) |
Resolution | 2.23 - 3.41 Å |
Structure data | EMDB-17693, PDB-8pix: EMDB-17714, PDB-8pjo: EMDB-17723, PDB-8pk2: EMDB-17726, PDB-8pk4: EMDB-50077: Cryo EM map of the type 2B polymorph of alpha-synuclein at pH 7.0. EMDB-50860: Cryo EM map of the type 2A polymorph of alpha-synuclein at pH 7.0. EMDB-50888, PDB-9fyp: |
Chemicals | ChemComp-CL: ChemComp-HOH: |
Source |
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Keywords | PROTEIN FIBRIL / amyloid / polymorphism |