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-Structure paper
Title | Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating. |
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Journal, issue, pages | Nat Commun, Vol. 9, Issue 1, Page 4985, Year 2018 |
Publish date | Nov 26, 2018 |
Authors | Ling Zhu / Yao Sun / Jinyan Fan / Bin Zhu / Lei Cao / Qiang Gao / Yanjun Zhang / Hongrong Liu / Zihe Rao / Xiangxi Wang / |
PubMed Abstract | Coxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, ...Coxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, utilizing the molecule KREMEN1 as an entry receptor, constitutes a KREMEN1-dependent subgroup within HEV-As. Currently, there is no vaccine or antiviral therapy available for treating diseases caused by CVA10. The atomic-resolution structure of the CVA10 virion, which is within the KREMEN1-dependent subgroup, shows significant conformational differences in the putative receptor binding sites and serotype-specific epitopes, when compared to the SCARB2-dependent subgroup of HEV-A, such as EV71, highlighting specific differences between the sub-groups. We also report two expanded structures of CVA10, an empty particle and uncoating intermediate at atomic resolution, as well as a medium-resolution genome structure reconstructed using a symmetry-mismatch method. Structural comparisons coupled with previous results, reveal an ordered signal transmission process for enterovirus uncoating, converting exo-genetic receptor-attachment inputs into a generic RNA release mechanism. |
External links | Nat Commun / PubMed:30478256 / PubMed Central |
Methods | EM (single particle) |
Resolution | 2.7 - 12.0 Å |
Structure data | EMDB-9642, PDB-6aks: EMDB-9643, PDB-6akt: EMDB-9644, PDB-6aku: EMDB-9652: |
Chemicals | ChemComp-SPH: |
Source |
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Keywords | VIRUS / picornavirus uncoating / receptor binding |