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Structure paper

TitleStructural and Biophysical Consequences of Sequence Variation in the B2a2 Loop of Mammalian Prions
Journal, issue, pagesTo be published
Publish dateAug 18, 2021 (structure data deposition date)
AuthorsGlynn, C. / Hernandez, E. / Gallagher-Jones, M. / Miao, J. / Rodriguez, J.A.
External linksSearch PubMed
MethodsEM (electron crystallography)
Resolution0.85 - 1.05 Å
Structure data

PDB-7rvc:
Segment from the human prion protein 168-176 EYSNQNNFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1.002 Å

PDB-7rvd:
Segment from the mouse/cow prion protein 168-176 QYSNQNNFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1.003 Å

PDB-7rve:
Segment from the S170N mutant of the human prion protein 168-176 EYNNQNNFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 0.85 Å

PDB-7rvf:
Segment from the Y169F mutant of the bank vole prion protein 168-176 QFNNQNNFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1 Å

PDB-7rvg:
Segment from rabbit/pig prion protein 168-176 QYSNQNSFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1 Å

PDB-7rvh:
Q172E mutant of the bank vole prion protein 168-176 QYNNENNFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 0.9 Å

PDB-7rvi:
Segment from naked mole rat (elk T174S) prion protein 168-176 QYNNQNSFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1.05 Å

PDB-7rvj:
Segment from the human prion protein 169-175 YSNQNNF
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1 Å

PDB-7rvk:
Segment from Y169G mutant of the human prion protein 169-175 GSNQNNF
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1 Å

PDB-7rvl:
Segment from the Y169F mutant of the human prion protein 168-176 EFSNQNNFV
Method: ELECTRON CRYSTALLOGRAPHY / Resolution: 1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CAC:
CACODYLATE ION

ChemComp-NA:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
  • myodes glareolus (Bank vole)
  • oryctolagus cuniculus (rabbit)
  • heterocephalus glaber (naked mole-rat)
KeywordsPROTEIN FIBRIL / amyloid / prion / fibril / mouse / cow / human prion / rabbit / pig / naked mole rat

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