タイトル | Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization |
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ジャーナル・号・ページ | Nat. Struct. Mol. Biol., Year 2024 |
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掲載日 | 2024年3月23日 (構造データの登録日) |
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著者 | Ivica J / Kejzar N / Ho H / Stockwell I / Kuchtiak V / Scrutton AM / Nakagawa T / Greger IH |
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リンク | Nat. Struct. Mol. Biol. / PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.57 - 3.69 Å |
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構造データ | EMDB-44232, PDB-9b5z: GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 2.71 Å EMDB-44233, PDB-9b60: GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 2.57 Å EMDB-44234, PDB-9b61: GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 2.81 Å EMDB-44244, PDB-9b63: GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 2.76 Å EMDB-44245, PDB-9b64: GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 3.56 Å EMDB-44248, PDB-9b67: GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 3.39 Å EMDB-44249, PDB-9b68: GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD 手法: EM (単粒子) / 解像度: 3.6 Å EMDB-44250, PDB-9b69: GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD 手法: EM (単粒子) / 解像度: 3.69 Å EMDB-44251, PDB-9b6a: GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 手法: EM (単粒子) / 解像度: 3.35 Å |
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化合物 | |
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由来 | ![](img/tx_mammal.gif) mus musculus (ハツカネズミ)![](img/tx_mammal.gif) rattus norvegicus (ドブネズミ)
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キーワード | TRANSPORT PROTEIN / AMPA receptor / ionotropic glutamate receptor / ion channel / auxiliary subunit |
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