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-Structure paper
Title | High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket |
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Journal, issue, pages | Nat Commun, Year 2024 |
Publish date | Aug 9, 2023 (structure data deposition date) |
![]() | Oken AC / Lisi NE / Krishnamurthy I / McCarthy AE / Godsey MH / Glasfeld A / Mansoor SE |
![]() | ![]() |
Methods | EM (single particle) |
Resolution | 2.49 - 2.78 Å |
Structure data | EMDB-41570, PDB-8tr5: EMDB-41581, PDB-8trj: EMDB-42976, PDB-8v4s: |
Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-ZN: ![]() ChemComp-NAG: ![]() ChemComp-PLM: ![]() ChemComp-NA: ![]() ChemComp-HOH: ![]()
ChemComp-KD9: |
Source |
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![]() | MEMBRANE PROTEIN / Ion Channel / Ligand-gate Ion Channel / P2X Receptor / Allosteric Antagonist / High-Affinity Agonist |