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Structure paper

TitleStructural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Journal, issue, pagesBiorxiv, Year 2022
Publish dateJun 22, 2021 (structure data deposition date)
AuthorsDe Vos, T. / Godar, M. / Bick, F. / Papageorgiou, A.C. / Evangelidis, T. / Markovic, I. / Mortier, E. / Dumoutier, L. / Tripsianes, K. / Blanchetot, C. / Savvides, S.N.
External linksBiorxiv / Search PubMed
MethodsX-ray diffraction / NMR (solution)
Resolution1.7 - 3.34 Å
Structure data

PDB-7ox1:
Fab 7D6: hIL-9 complex
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

PDB-7ox2:
Fab 6E2: hIL-9 complex
Method: X-RAY DIFFRACTION / Resolution: 3.34 Å

PDB-7ox3:
Fab 6D3: hIL-9 complex
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-7ox4:
Mouse interleukin-9 in complex with Fab 35D8.
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7ox5:
hIL-9:hIL-9Ra complex
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

PDB-7ox6:
Solution structure of human interleukin-9
Method: SOLUTION NMR

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsCYTOKINE / IL-9 / complex / Fab / four-helical bundle

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