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Structure paper

TitleStructural basis for late maturation steps of mitochondrial respiratory chain complex IV within the human respirasome
Journal, issue, pagesTo Be Published
Publish dateJan 14, 2025 (structure data deposition date)
AuthorsNguyen MD / Khajawa A / Rorbach J
External linksSearch PubMed
MethodsEM (single particle)
Resolution2.52 - 2.63 Å
Structure data

52525

9hzl

EMDB-52525, PDB-9hzl:
High resolution cryo-EM structure of human complex III in mitochondria
Method: EM (single particle) / Resolution: 2.52 Å

52619

9i4i

EMDB-52619, PDB-9i4i:
High resolution Cryo-EM structure of human complex I in mitochondria
Method: EM (single particle) / Resolution: 2.63 Å

Chemicals

ChemComp-CDL:
CARDIOLIPIN / phospholipid*YM

ChemComp-3PE:
1,2-Distearoyl-sn-glycerophosphoethanolamine / phospholipid*YM

ChemComp-FES:
FE2/S2 (INORGANIC) CLUSTER

ChemComp-PLX:
(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL / phospholipid*YM

ChemComp-HEC:
HEME C

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-PEE:
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE, phospholipid*YM

ChemComp-U10:
UBIQUINONE-10

ChemComp-PC1:
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE / phospholipid*YM

ChemComp-8Q1:
S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Human mitochondria / respirasome complex / cytochrome bc1 complex / CoQH2-cytochrome c reductase / complex III / complex I / NADH dehydrogenase

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