タイトル | Structural characterization of antibody-responses from Zolgensma treatment guides the design of a capsid suitable for redosing |
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ジャーナル・号・ページ | Nat Commun, Year 2025 |
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掲載日 | 2024年3月25日 (構造データの登録日) |
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著者 | Mietzsch M / Nelson AR / Hsi J / Zachary J / Potts L / Chipman P / Ghanem M / Alexander IE / Logan GJ / Huiskonen J / McKenna R |
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リンク | PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.54 - 3.47 Å |
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構造データ | EMDB-44271, PDB-9b6n: Fab1-1 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 3.31 Å EMDB-44272, PDB-9b6o: Fab1-2 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 2.61 Å EMDB-44273, PDB-9b6p: Fab1-3 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 3.13 Å EMDB-44274, PDB-9b6q: Fab1-4 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 2.77 Å EMDB-44275, PDB-9b6r: Fab1-5 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 3.19 Å EMDB-44276, PDB-9b6s: Fab1-6 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 3.47 Å EMDB-44277, PDB-9b6t: Fab1-7 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 2.54 Å EMDB-44314, PDB-9b7k: Fab2-1 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 2.75 Å EMDB-44315, PDB-9b7l: Fab2-2 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 2.82 Å EMDB-44316, PDB-9b7m: Fab2-3 in complex with the capsid of Adeno-associated virus type 9 手法: EM (単粒子) / 解像度: 2.82 Å |
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化合物 | |
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由来 |  adeno-associated virus (アデノ随伴ウイルス) homo sapiens (ヒト)
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キーワード | VIRAL PROTEIN/IMMUNE SYSTEM / Adeno-associated virus / AAV / capsid / Fab-complex / antibody / NAb / VIRUS / VIRAL PROTEIN-IMMUNE SYSTEM complex |
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