Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Identification of KLHL12 Ligands Using Fragment-Based Methods.
Journal, issue, pages	J. Med. Chem., Vol. 69, Page 7709-7731, Year 2026
Publish date	Sep 11, 2025 (structure data deposition date)
Authors	Waterson, A.G. / Vadukoot, A. / Jana, S. / Cui, J. / Luong, K. / Rietz, T.A. / Madrigal-Carrillo, E.A. / Lehmann, B.D. / Sensintaffar, J.L. / Zhao, B. ...Waterson, A.G. / Vadukoot, A. / Jana, S. / Cui, J. / Luong, K. / Rietz, T.A. / Madrigal-Carrillo, E.A. / Lehmann, B.D. / Sensintaffar, J.L. / Zhao, B. / Amporndanai, K. / Petros, Z.A. / Scaggs, W.R. / Chacon Simon, S. / Vekariya, R.H. / Kim, K. / Thangaraj, M. / Christov, P.P. / South, T.M. / Sai, J. / Thiruvaipati, A. / Schmidt, C.R. / Eells, R. / Moore, W.J. / Olejniczak, E.T. / Phan, J. / Fesik, S.W.
External links	J. Med. Chem. / PubMed:41906311
Methods	X-ray diffraction
Resolution	1.01 - 2.7 Å
Structure data	PDB-9y8j: Crystal structure of the Kelch domain of human KLHL12 with compound 1 Method: X-RAY DIFFRACTION / Resolution: 2.7 Å PDB-9y8k: Crystal structure of the Kelch domain of human KLHL12 with compound 7k Method: X-RAY DIFFRACTION / Resolution: 1.27 Å PDB-9y8l: Crystal structure of the Kelch domain of human KLHL12 with compound 8e Method: X-RAY DIFFRACTION / Resolution: 1.27 Å PDB-9y8m: Crystal structure of the Kelch domain of human KLHL12 with compound 8i Method: X-RAY DIFFRACTION / Resolution: 1.334 Å PDB-9y8n: Crystal structure of the Kelch domain of human KLHL12 with compound 8m Method: X-RAY DIFFRACTION / Resolution: 1.308 Å PDB-9y8o: Crystal structure of the Kelch domain of human KLHL12 with compound 9c Method: X-RAY DIFFRACTION / Resolution: 1.286 Å PDB-9y8q: Crystal structure of the Kelch domain of human KLHL12 with compound 9e Method: X-RAY DIFFRACTION / Resolution: 1.2 Å PDB-9y8r: Crystal structure of the Kelch domain of human KLHL12 with compound 9h Method: X-RAY DIFFRACTION / Resolution: 1.334 Å PDB-9y8s: Crystal structure of the Kelch domain of human KLHL12 with compound 9k Method: X-RAY DIFFRACTION / Resolution: 1.286 Å PDB-9y8t: Crystal structure of the Kelch domain of human KLHL12 with compound 10b Method: X-RAY DIFFRACTION / Resolution: 1.4 Å PDB-9y8u: Crystal structure of the Kelch domain of human KLHL12 with compound 10j Method: X-RAY DIFFRACTION / Resolution: 1.01 Å PDB-9y8v: Crystal structure of the Kelch domain of human KLHL12 with compound 10q Method: X-RAY DIFFRACTION / Resolution: 1.271 Å
Chemicals	PDB-1cts: CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF TWO DIFFERENT FORMS OF CITRATE SYNTHASE AT 2.7 AND 1.7 ANGSTROMS RESOLUTION PDB-1ctr: DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX ChemComp-HOH: WATER PDB-1ctq: STRUCTURE OF P21RAS IN COMPLEX WITH GPPNHP AT 100 K PDB-1cte: CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN PDB-1ctl: STRUCTURE OF THE CARBOXY-TERMINAL LIM DOMAIN FROM THE CYSTEINE RICH PROTEIN CRP PDB-1ctm: CRYSTAL STRUCTURE OF CHLOROPLAST CYTOCHROME F REVEALS A NOVEL CYTOCHROME FOLD AND UNEXPECTED HEME LIGATION PDB-1cto: NMR STRUCTURE OF THE C-TERMINAL DOMAIN OF THE LIGAND-BINDING REGION OF MURINE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR, MINIMIZED AVERAGE STRUCTURE ChemComp-GOL: GLYCEROL PDB-1ctp: STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION PDB-1ctn: CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION PDB-1ctj: CRYSTAL STRUCTURE OF CYTOCHROME C6 PDB-1ctk: Unknown entry PDB-1ctf: STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RIBOSOMAL PROTEIN L7/L12 FROM ESCHERICHIA COLI AT 1.7 ANGSTROMS
Source	homo sapiens (human)
Keywords	LIGASE / E3 ligase / fragment-based drug discovery / PROTAC