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TitleStructural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus.
Journal, issue, pagesNat Commun, Vol. 13, Page 7298-7298, Year 2022
Publish dateJun 15, 2022 (structure data deposition date)
AuthorsDurie, I.A. / Tehrani, Z.R. / Karaaslan, E. / Sorvillo, T.E. / McGuire, J. / Golden, J.W. / Welch, S.R. / Kainulainen, M.H. / Harmon, J.R. / Mousa, J.J. ...Durie, I.A. / Tehrani, Z.R. / Karaaslan, E. / Sorvillo, T.E. / McGuire, J. / Golden, J.W. / Welch, S.R. / Kainulainen, M.H. / Harmon, J.R. / Mousa, J.J. / Gonzalez, D. / Enos, S. / Koksal, I. / Yilmaz, G. / Karakoc, H.N. / Hamidi, S. / Albay, C. / Spengler, J.R. / Spiropoulou, C.F. / Garrison, A.R. / Sajadi, M.M. / Bergeron, E. / Pegan, S.D.
External linksNat Commun / PubMed:36435827
MethodsX-ray diffraction
Resolution3.21 - 3.86 Å
Structure data

PDB-8dc5:
CCHFV GP38 Hoti/Kosovo
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

PDB-8dcy:
CCHFV GP38 Hoti/Kosovo bound with 13G8 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.62 Å

PDB-8ddk:
CCHFV GP38 Hoti/Kosovo bound with CC5_17
Method: X-RAY DIFFRACTION / Resolution: 3.86 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-IOD:
IODIDE ION

ChemComp-HOH:
WATER

Source
  • crimean-congo hemorrhagic fever orthonairovirus
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / Crimean-Congo Hemorrhagic Fever / CCHFV / Glycoprotein / GP38 / Hoti / Kosovo / 13G8 / Fab / CC5-17 / mAb

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