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Structure paper

TitleValidation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.
Journal, issue, pagesSci Rep, Vol. 12, Page 12068-12068, Year 2022
Publish dateJul 12, 2021 (structure data deposition date)
AuthorsLiu, C. / Liu, H. / Dasgupta, M. / Hellman, L.M. / Zhang, X. / Qu, K. / Xue, H. / Wang, Y. / Fan, F. / Chang, Q. ...Liu, C. / Liu, H. / Dasgupta, M. / Hellman, L.M. / Zhang, X. / Qu, K. / Xue, H. / Wang, Y. / Fan, F. / Chang, Q. / Yu, D. / Ge, L. / Zhang, Y. / Cui, Z. / Zhang, P. / Heller, B. / Zhang, H. / Shi, B. / Baker, B.M.
External linksSci Rep / PubMed:35840635
MethodsX-ray diffraction
Resolution2.547 - 2.82 Å
Structure data

PDB-7re7:
TCR mimic antibody (Fab fragment) in complex with AFP/HLA-A*02
Method: X-RAY DIFFRACTION / Resolution: 2.547 Å

PDB-7re8:
Class I MHC (HLA-A*02) presenting alpha fetoprotein peptide (AFP)
Method: X-RAY DIFFRACTION / Resolution: 2.82 Å

PDB-7re9:
TCR mimic antibody (Fab fragment)
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-FMT:
FORMIC ACID

ChemComp-HOH:
WATER

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / TCR mimic antibody (Fab fragment) / class I Major Histocompatibility Complex (HLA-A*02) / alpha fetoprotein peptide. / Alpha fetoprotein peptide (AFP).

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