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TitleStructural basis of FPR2 in recognition of Aβ and neuroprotection by humanin.
Journal, issue, pagesNat Commun, Vol. 13, Issue 1, Page 1775, Year 2022
Publish dateApr 1, 2022
AuthorsYa Zhu / Xiaowen Lin / Xin Zong / Shuo Han / Mu Wang / Yuxuan Su / Limin Ma / Xiaojing Chu / Cuiying Yi / Qiang Zhao / Beili Wu /
PubMed AbstractFormyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the β amyloid peptide Aβ and serves as a receptor for humanin, a peptide that protects neuronal cells from damage ...Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the β amyloid peptide Aβ and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by Aβ, implying its involvement in the pathogenesis of Alzheimer's disease (AD). However, the interaction pattern between FPR2 and Aβ or humanin remains unknown. Here we report the structures of FPR2 bound to G and Aβ or N-formyl humanin (fHN). Combined with functional data, the structures reveal two critical regions that govern recognition and activity of Aβ and fHN, including a polar binding cavity within the receptor helical bundle and a hydrophobic binding groove in the extracellular region. In addition, the structures of FPR2 and FPR1 in complex with different formyl peptides were determined, providing insights into ligand recognition and selectivity of the FPR family. These findings uncover key factors that define the functionality of FPR2 in AD and other inflammatory diseases and would enable drug development.
External linksNat Commun / PubMed:35365641 / PubMed Central
MethodsEM (single particle)
Resolution2.8 - 3.3 Å
Structure data

32858

7wvu

EMDB-32858, PDB-7wvu:
Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1
Method: EM (single particle) / Resolution: 3.3 Å

32859

7wvv

EMDB-32859, PDB-7wvv:
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2
Method: EM (single particle) / Resolution: 2.9 Å

32860

7wvw

EMDB-32860, PDB-7wvw:
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2
Method: EM (single particle) / Resolution: 3.1 Å

32861

7wvx

EMDB-32861, PDB-7wvx:
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2
Method: EM (single particle) / Resolution: 2.8 Å

32862

7wvy

EMDB-32862, PDB-7wvy:
Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
Method: EM (single particle) / Resolution: 3.0 Å

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / G protein-coupled receptor / formyl peptide receptor / FPR1 / fMLF / FPR2 / fMLFII / fMYFINILTL / humanin / Abeta42

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