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Structure paper

TitleStructural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies.
Journal, issue, pagesScience, Vol. 375, Page 104-109, Year 2022
Publish dateAug 20, 2020 (structure data deposition date)
AuthorsMishra, A.K. / Hellert, J. / Freitas, N. / Guardado-Calvo, P. / Haouz, A. / Fels, J.M. / Maurer, D.P. / Abelson, D.M. / Bornholdt, Z.A. / Walker, L.M. ...Mishra, A.K. / Hellert, J. / Freitas, N. / Guardado-Calvo, P. / Haouz, A. / Fels, J.M. / Maurer, D.P. / Abelson, D.M. / Bornholdt, Z.A. / Walker, L.M. / Chandran, K. / Cosset, F.L. / McLellan, J.S. / Rey, F.A.
External linksScience / PubMed:34793197
MethodsX-ray diffraction
Resolution2.1 - 2.989 Å
Structure data

PDB-7a59:
Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Orthorhombic Crystal Form)
Method: X-RAY DIFFRACTION / Resolution: 2.197 Å

PDB-7a5a:
Crimean-Congo Hemorrhagic Fever Virus Envelope Glycoprotein Gc W1191H/W1197A/W1199A Mutant in Postfusion Conformation (Monoclinic Crystal Form)
Method: X-RAY DIFFRACTION / Resolution: 2.989 Å

PDB-7kx4:
Anti-CCHFV ADI-36121 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-7l7r:
CCHFV Gc prefusion monomer bound to ADI-36121 and ADI-37801 Fabs
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CL:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • crimean-congo hemorrhagic fever virus strain ibar10200
  • crimean-congo hemorrhagic fever virus (strain nigeria/ibar10200/1970)
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / Virus Entry / Class II Membrane Fusion Protein / IMMUNE SYSTEM / antibody / Fab / fusion protein / Fab complex / class II fusion

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