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Structure paper

TitleRapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.
Journal, issue, pagesPlos One, Vol. 15, Page e0232311-e0232311, Year 2020
Publish dateApr 5, 2020 (structure data deposition date)
AuthorsLieu, R. / Antonysamy, S. / Druzina, Z. / Ho, C. / Kang, N.R. / Pustilnik, A. / Wang, J. / Atwell, S.
External linksPlos One / PubMed:32915778
MethodsX-ray diffraction
Resolution1.36 - 2.96 Å
Structure data

PDB-6wg8:
Fab portion of dupilumab with Crystal Kappa design
Method: X-RAY DIFFRACTION / Resolution: 1.36 Å

PDB-6wgb:
Crystal structure of the fab portion of dupilumab
Method: X-RAY DIFFRACTION / Resolution: 1.99 Å

PDB-6wgj:
Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6wgk:
Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

PDB-6wgl:
Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor
Method: X-RAY DIFFRACTION / Resolution: 2.82 Å

PDB-6wio:
Fab antigen complex
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

PDB-6wir:
Fab antigen complex
Method: X-RAY DIFFRACTION / Resolution: 2.96 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Dupilumab / hIL4R / CYTOKINE/IMMUNE SYSTEM / Fab / Il-17 / CYTOKINE / CYTOKINE-IMMUNE SYSTEM complex

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