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-Structure paper
Title | Structures of Hsp90 alpha and Hsp90 beta bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity. |
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Journal, issue, pages | Proteins, Vol. 87, Page 869-877, Year 2019 |
Publish date | Nov 30, 2018 (structure data deposition date) |
Authors | Huck, J.D. / Que, N.L.S. / Sharma, S. / Taldone, T. / Chiosis, G. / Gewirth, D.T. |
External links | Proteins / PubMed:31141217 |
Methods | X-ray diffraction |
Resolution | 1.43760580022 - 3.0922814017 Å |
Structure data | PDB-6n8w: PDB-6n8x: PDB-6n8y: PDB-6olx: |
Chemicals | ChemComp-GOL: ChemComp-HOH: ChemComp-KFY: |
Source |
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Keywords | CHAPERONE / Heat-Shock / HSP90 / Cytosolic / chaperone/chaperone inhibitor / Inhibitor / Cancer / Cytosol / chaperone-chaperone inhibitor complex |