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Structure paper

TitleTopological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Journal, issue, pagesScience, Vol. 364, Year 2019
Publish dateOct 4, 2018 (structure data deposition date)
AuthorsMohan, K. / Ueda, G. / Kim, A.R. / Jude, K.M. / Fallas, J.A. / Guo, Y. / Hafer, M. / Miao, Y. / Saxton, R.A. / Piehler, J. ...Mohan, K. / Ueda, G. / Kim, A.R. / Jude, K.M. / Fallas, J.A. / Guo, Y. / Hafer, M. / Miao, Y. / Saxton, R.A. / Piehler, J. / Sankaran, V.G. / Baker, D. / Garcia, K.C.
External linksScience / PubMed:31123111
MethodsX-ray diffraction
Resolution1.21 - 5.101 Å
Structure data

PDB-6moe:
Monomeric DARPin E2 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 2.091 Å

PDB-6mof:
Monomeric DARPin G2 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 2.894 Å

PDB-6mog:
Dimeric DARPin C_R3
Method: X-RAY DIFFRACTION / Resolution: 1.21 Å

PDB-6moh:
Dimeric DARPin C_R3 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-6moi:
Dimeric DARPin C_angle_R5 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 2.065 Å

PDB-6moj:
Dimeric DARPin A_angle_R5 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 2.431 Å

PDB-6mok:
Dimeric DARPin A_distance_R7 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 5.101 Å

PDB-6mol:
Monoextended DARPin M_R12 complex with EpoR
Method: X-RAY DIFFRACTION / Resolution: 3.163 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-NA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-MG:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-TAR:
D(-)-TARTARIC ACID

ChemComp-GOL:
GLYCEROL

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsBIOSYNTHETIC PROTEIN / Complex / Receptor / DARPin

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