EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
ジャーナル・号・ページ	Antimicrob. Agents Chemother., Vol. 62, Year 2018
掲載日	2018年3月8日 (構造データの登録日)
著者	Zhang, H. / Ma, G. / Zhu, Y. / Zeng, L. / Ahmad, A. / Wang, C. / Pang, B. / Fang, H. / Zhao, L. / Hao, Q.
リンク	Antimicrob. Agents Chemother. / PubMed:30150473
手法	X線回折
解像度	0.95 - 1.55 Å
構造データ	PDB-5zge: Crystal structure of NDM-1 at pH5.5 (Bis-Tris) in complex with hydrolyzed ampicillin 手法: X-RAY DIFFRACTION / 解像度: 1 Å PDB-5zgf: Crystal structure of NDM-1 Q123G mutant 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-5zgi: Crystal structure of NDM-1 at pH6.5 (Succinate) with 1 molecule per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 0.98 Å PDB-5zgp: Crystal structure of NDM-1 at pH6.2 (Bis-Tris) in complex with hydrolyzed ampicillin 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-5zgq: Crystal structure of NDM-1 at pH7.5 (Tris-HCl, (NH4)2SO4) in complex with hydrolyzed ampicillin 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-5zgr: Crystal structure of NDM-1 at pH7.3 (HEPES) in complex with hydrolyzed ampicillin 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-5zgt: Crystal structure of NDM-1 at pH7.5 (HEPES) with 2 molecules per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 1.2 Å PDB-5zgu: Crystal structure of NDM-1 at pH7.0 (HEPES) with 2 molecules per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-5zgv: Crystal structure of NDM-1 at pH8.0 (Tris) with 2 molecules per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 1.15 Å PDB-5zgw: Crystal structure of NDM-1 at pH7.5 with 1 molecule per asymmetric unit (crystallized at succinate pH5.5 and soaked at succinate pH7.5) 手法: X-RAY DIFFRACTION / 解像度: 0.95 Å PDB-5zgx: Crystal structure of NDM-1 at pH7.5 (Succinate) with 1 molecule per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 0.95 Å PDB-5zgy: Crystal structure of NDM-1 at pH7.5 (Bis-Tris) with 1 molecule per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 0.95 Å PDB-5zgz: Crystal structure of NDM-1 at pH7.5 (Imidazole) with 1 molecule per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 0.95 Å PDB-5zh1: Crystal structure of NDM-1 at pH7.5 (Imidazole) with 2 molecules per asymmetric unit 手法: X-RAY DIFFRACTION / 解像度: 1.05 Å
化合物	ChemComp-ZZ7: (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid / (αR,2R)-α-[[(R)-アミノフェニルアセチル]アミノ]-4β-カルボキシ-5,5-ジメチルチアゾリジン-2α(以下略) ChemComp-ZN: Unknown entry ChemComp-OH: HYDROXIDE ION / ヒドロキシド ChemComp-HOH: WATER ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-SIN: SUCCINIC ACID / コハク酸 ChemComp-PEG: DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / HEPES / pH緩衝剤YM ChemComp-IMD*: IMIDAZOLE / イミダゾリウム
由来	klebsiella pneumoniae (肺炎桿菌)
キーワード	HYDROLASE/ANTIBIOTIC / NDM-1 / metallo-beta-lactamase / antibiotic resistent / conformational change / ANTIBIOTIC / HYDROLASE-ANTIBIOTIC complex / HYDROLASE