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TitleScreening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization.
Journal, issue, pagesAntibiotics (Basel), Vol. 7, Year 2018
Publish dateFeb 5, 2016 (structure data deposition date)
AuthorsPandey, P. / Verma, V. / Dhar, S.K. / Gourinath, S.
External linksAntibiotics (Basel) / PubMed:29324718
MethodsX-ray diffraction
Resolution1.97 - 2.3 Å
Structure data

PDB-5fve:
Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobenzamide
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-5fxt:
Crystal Structure of Helicobacter pylori beta clamp in complex with Carprofen
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-5g4q:
H.pylori Beta clamp in complex with 5-chloroisatin
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-2HO:
3,4-difluorobenzamide

ChemComp-HOH:
WATER

ChemComp-0LA:
(2S)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid

ChemComp-2HQ:
5-chloro-1H-indole-2,3-dione

Source
  • helicobacter pylori (bacteria)
KeywordsTRANSFERASE / DNA CLAMP / SLIDING CLAMP / DNA SLIDING CLAMP / PROCESSIVITY PROMOTING FACTOR

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