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-Structure paper
Title | Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 12448-12453, Year 2017 |
Publish date | Mar 20, 2017 (structure data deposition date) |
![]() | Morvan, F. / Rondeau, J.-M. / Zou, C. / Minetti, G. / Scheufler, C. / Scharenberg, M. / Jacobi, C. / Brebbia, P. / Ritter, V. / Toussaint, G. ...Morvan, F. / Rondeau, J.-M. / Zou, C. / Minetti, G. / Scheufler, C. / Scharenberg, M. / Jacobi, C. / Brebbia, P. / Ritter, V. / Toussaint, G. / Koelbing, C. / Leber, X. / Schilb, A. / Witte, F. / Lehmann, S. / Koch, E. / Geisse, S. / Glass, D.J. / Lach-Trifilieff, E. |
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Methods | X-ray diffraction |
Resolution | 1.78 - 3.35 Å |
Structure data | ![]() PDB-5ngv: ![]() PDB-5nh3: ![]() PDB-5nhr: ![]() PDB-5nhw: |
Chemicals | ![]() ChemComp-PG4: ![]() ChemComp-HOH: ![]() ChemComp-NAG: ![]() ChemComp-GOL: |
Source |
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![]() | TRANSFERASE / three-finger toxin fold / antibody Fv fragment / OTHER / EPITOPE MAPPING / IMMUNE SYSTEM / immunoglobulin / antibody Fab fragment / anti-Activin receptor type-2 antibody |