EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Non-classical transpeptidases yield insight into new antibacterials.
ジャーナル・号・ページ	Nat. Chem. Biol., Vol. 13, Page 54-61, Year 2017
掲載日	2015年9月18日 (構造データの登録日)
著者	Kumar, P. / Kaushik, A. / Lloyd, E.P. / Li, S.G. / Mattoo, R. / Ammerman, N.C. / Bell, D.T. / Perryman, A.L. / Zandi, T.A. / Ekins, S. ...Kumar, P. / Kaushik, A. / Lloyd, E.P. / Li, S.G. / Mattoo, R. / Ammerman, N.C. / Bell, D.T. / Perryman, A.L. / Zandi, T.A. / Ekins, S. / Ginell, S.L. / Townsend, C.A. / Freundlich, J.S. / Lamichhane, G.
リンク	Nat. Chem. Biol. / PubMed:27820797
手法	X線回折
解像度	1.79 - 2.25 Å
構造データ	PDB-5du7: Crystal structure of ldtMt2 at 1.79 Angstrom resolution 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-5duj: Crystal structure of ldtMt2 in complex with Faropenem adduct 手法: X-RAY DIFFRACTION / 解像度: 2.17 Å PDB-5dvp: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with Doripenem adduct 手法: X-RAY DIFFRACTION / 解像度: 2.18 Å PDB-5dzj: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T206 in conformation A 手法: X-RAY DIFFRACTION / 解像度: 2.095 Å PDB-5dzp: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T206 in conformation B 手法: X-RAY DIFFRACTION / 解像度: 2.19 Å PDB-5e1g: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T208 手法: X-RAY DIFFRACTION / 解像度: 1.852 Å PDB-5e1i: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T210 手法: X-RAY DIFFRACTION / 解像度: 2.003 Å PDB-5e51: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 with Faropenem adduct 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-5e5l: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 1 at 1.89 Angstrom 手法: X-RAY DIFFRACTION / 解像度: 1.89 Å PDB-5k69: Crystal structure of Mycobacterium tuberculosis L,D-transpeptidase 2 with carbapenem drug T224 手法: X-RAY DIFFRACTION / 解像度: 2.001 Å
化合物	ChemComp-HOH: WATER ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-BME: BETA-MERCAPTOETHANOL / 2-メルカプトエタノ-ル ChemComp-DGF: (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid ChemComp-DRW: (2S,3R,4S)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid ChemComp-POA: PHOSPHONOACETALDEHYDE / ホスホノアセトアルデヒド ChemComp-6B7: (2~{R},3~{R},4~{R})-4-methyl-3-(2-oxidanylidene-2-propoxy-ethyl)sulfanyl-5-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-2-carboxylic acid ChemComp-T8G: (2~{S},3~{R},4~{R})-4-(2-cyclohexyloxy-2-oxidanylidene-ethyl)sulfanyl-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-6B8: (2S,3R,4R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-(methylsulfanyl)-3,4-dihydro-2H-pyrrole-5-carboxylic acid ChemComp-GOL: GLYCEROL / グリセロ-ル ChemComp-5KO: (3R)-3-hydroxybutanal ChemComp-6QR: (2~{S},3~{R},4~{R})-4-(1~{H}-indol-3-ylsulfanyl)-3-methyl-2-[(2~{S},3~{S})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid
由来	mycobacterium tuberculosis (結核菌) mycobacterium tuberculosis (strain atcc 25618 / h37rv) (結核菌) mycobacterium tuberculosis (strain cdc 1551 / oshkosh) (結核菌)
キーワード	TRANSFERASE / Peptidoglycan synthesis enzyme / cell wall enzyme / LD-TRANSPEPTIDASE / L / D-transpeptidase 1 / ldtMt1 / Mycobacterium tuberculosis / TRANSFERASE/TRANSFERASE INHIBITOR / peptidase / IgD_like domain / YkuD domain / TRANSFERASE-TRANSFERASE INHIBITOR complex