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Structure paper

TitleStructural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 161, Page 1280-1292, Year 2015
Publish dateDec 8, 2014 (structure data deposition date)
AuthorsZhou, T. / Lynch, R.M. / Chen, L. / Acharya, P. / Wu, X. / Doria-Rose, N.A. / Joyce, M.G. / Lingwood, D. / Soto, C. / Bailer, R.T. ...Zhou, T. / Lynch, R.M. / Chen, L. / Acharya, P. / Wu, X. / Doria-Rose, N.A. / Joyce, M.G. / Lingwood, D. / Soto, C. / Bailer, R.T. / Ernandes, M.J. / Kong, R. / Longo, N.S. / Louder, M.K. / McKee, K. / O'Dell, S. / Schmidt, S.D. / Tran, L. / Yang, Z. / Druz, A. / Luongo, T.S. / Moquin, S. / Srivatsan, S. / Yang, Y. / Zhang, B. / Zheng, A. / Pancera, M. / Kirys, T. / Georgiev, I.S. / Gindin, T. / Peng, H.P. / Yang, A.S. / Mullikin, J.C. / Gray, M.D. / Stamatatos, L. / Burton, D.R. / Koff, W.C. / Cohen, M.S. / Haynes, B.F. / Casazza, J.P. / Connors, M. / Corti, D. / Lanzavecchia, A. / Sattentau, Q.J. / Weiss, R.A. / West, A.P. / Bjorkman, P.J. / Scheid, J.F. / Nussenzweig, M.C. / Shapiro, L. / Mascola, J.R. / Kwong, P.D.
External linksCell(Cambridge,Mass. ) / PubMed:26004070
MethodsX-ray diffraction
Resolution1.8 - 3.452 Å
Structure data

PDB-4rwy:
Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC131 in complex with HIV-1 clade B YU2 gp120
Method: X-RAY DIFFRACTION / Resolution: 2.128 Å

PDB-4rx4:
Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC134 in complex with HIV-1 clade A Q842.d12 gp120
Method: X-RAY DIFFRACTION / Resolution: 3.45 Å

PDB-4ydi:
Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17
Method: X-RAY DIFFRACTION / Resolution: 3.452 Å

PDB-4ydj:
Crystal structure of broadly and potently neutralizing antibody 44-VRC13.01 in complex with HIV-1 clade AE strain 93TH057 gp120
Method: X-RAY DIFFRACTION / Resolution: 2.308 Å

PDB-4ydk:
Crystal structure of broadly and potently neutralizing antibody C38-VRC16.01 in complex with HIV-1 clade AE strain 93TH057 gp120
Method: X-RAY DIFFRACTION / Resolution: 2.051 Å

PDB-4ydl:
Crystal structure of broadly and potently neutralizing antibody C38-VRC18.02 in complex with HIV-1 clade AE strain 93TH057gp120
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-4ye4:
Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120
Method: X-RAY DIFFRACTION / Resolution: 2.72 Å

PDB-4yfl:
Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120
Method: X-RAY DIFFRACTION / Resolution: 3.387 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM / HEPES

ChemComp-EDO:
1,2-ETHANEDIOL / Ethylene glycol

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER / Water

ChemComp-SO4:
SULFATE ION / Sulfate

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM / Isopropyl alcohol

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER / Diethylene glycol

ChemComp-CL:
Unknown entry / Chloride

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-NHE:
2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID / pH buffer*YM / CHES (buffer)

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
  • human immunodeficiency virus
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HIV-1 attachment protein / Broadly neutralizing antibody 8ANC131 / VIRAL PROTEIN-IMMUNE SYSTEM complex / Broadly neutralizing antibody / IMMUNE SYSTEM / Antibody / HIV-1 / HIV1 / gp120 / complex / HIV-1 CD4 binding site

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