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Structure paper

TitleStructures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Journal, issue, pagesImmunity, Vol. 36, Page 561-571, Year 2012
Publish dateApr 19, 2011 (structure data deposition date)
AuthorsJin, T. / Perry, A. / Jiang, J. / Smith, P. / Curry, J.A. / Unterholzner, L. / Jiang, Z. / Horvath, G. / Rathinam, V.A. / Johnstone, R.W. ...Jin, T. / Perry, A. / Jiang, J. / Smith, P. / Curry, J.A. / Unterholzner, L. / Jiang, Z. / Horvath, G. / Rathinam, V.A. / Johnstone, R.W. / Hornung, V. / Latz, E. / Bowie, A.G. / Fitzgerald, K.A. / Xiao, T.S.
External linksImmunity / PubMed:22483801
MethodsX-ray diffraction
Resolution1.8 - 2.55 Å
Structure data

PDB-3rln:
Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors
Method: X-RAY DIFFRACTION / Resolution: 2.251 Å

PDB-3rlo:
Structural Basis of Cytosolic DNA Recognition by Innate Receptors
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-3rn2:
Structural Basis of Cytosolic DNA Recognition by Innate Immune Receptors
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-3rn5:
Structural basis of cytosolic DNA recognition by innate immune receptors
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3rnu:
Structural Basis of Cytosolic DNA Sensing by Innate Immune Receptors
Method: X-RAY DIFFRACTION / Resolution: 2.502 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / HIN200/OB fold/DNA binding / cytosolic DNA sensor/DNA binding / DNA / cytosol / DNA binding/cytosolic DNA sensor / Immune system/DNA / CYTOSOLIC DNA SENSOR / INFLAMMASOME / DNA BINDING / CYTOSOLIC / Immune system-DNA complex / OB FOLD / transcription activator/dna / IMMUNE RESPONSE-DNA COMPLEX / transcription activator-dna complex

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