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TitleStructure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Journal, issue, pagesNature, Vol. 480, Page 336-343, Year 2011
Publish dateAug 9, 2011 (structure data deposition date)
AuthorsMcLellan, J.S. / Pancera, M. / Carrico, C. / Gorman, J. / Julien, J.P. / Khayat, R. / Louder, R. / Pejchal, R. / Sastry, M. / Dai, K. ...McLellan, J.S. / Pancera, M. / Carrico, C. / Gorman, J. / Julien, J.P. / Khayat, R. / Louder, R. / Pejchal, R. / Sastry, M. / Dai, K. / O'Dell, S. / Patel, N. / Shahzad-Ul-Hussan, S. / Yang, Y. / Zhang, B. / Zhou, T. / Zhu, J. / Boyington, J.C. / Chuang, G.Y. / Diwanji, D. / Georgiev, I. / Do Kwon, Y. / Lee, D. / Louder, M.K. / Moquin, S. / Schmidt, S.D. / Yang, Z.Y. / Bonsignori, M. / Crump, J.A. / Kapiga, S.H. / Sam, N.E. / Haynes, B.F. / Burton, D.R. / Koff, W.C. / Walker, L.M. / Phogat, S. / Wyatt, R. / Orwenyo, J. / Wang, L.X. / Arthos, J. / Bewley, C.A. / Mascola, J.R. / Nabel, G.J. / Schief, W.R. / Ward, A.B. / Wilson, I.A. / Kwong, P.D.
External linksNature / PubMed:22113616
MethodsX-ray diffraction
Resolution1.797 - 3.281 Å
Structure data

PDB-3tcl:
Crystal Structure of HIV-1 Neutralizing Antibody CH04
Method: X-RAY DIFFRACTION / Resolution: 1.906 Å

PDB-3u1s:
Crystal structure of human Fab PGT145, a broadly reactive and potent HIV-1 neutralizing antibody
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-3u2s:
Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain ZM109
Method: X-RAY DIFFRACTION / Resolution: 1.797 Å

PDB-3u36:
Crystal Structure of PG9 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.281 Å

PDB-3u46:
CH04H/CH02L P212121
Method: X-RAY DIFFRACTION / Resolution: 2.906 Å

PDB-3u4b:
CH04H/CH02L Fab P4
Method: X-RAY DIFFRACTION / Resolution: 2.893 Å

PDB-3u4e:
Crystal Structure of PG9 Fab in Complex with V1V2 Region from HIV-1 strain CAP45
Method: X-RAY DIFFRACTION / Resolution: 2.185 Å

Chemicals

ChemComp-IMD:
IMIDAZOLE

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-BU3:
(R,R)-2,3-BUTANEDIOL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / Ig / Immunoglobulin / IgG / broadly neutralizing antibody / HIV-1 gp120 / greek key / immune recognition / gp120 binding / Immunogloblulin / HIV-1 Antibodies / V1V2-Directed / HIV-1 / NEUTRALIZING ANTIBODIES / LONG CDRH3

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