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TitleStructures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
Journal, issue, pagesJ. Biol. Chem., Vol. 285, Page 38204-, Year 2010
Publish dateOct 30, 2009 (structure data deposition date)
AuthorsFroese, D.S. / Kochan, G. / Muniz, J.R.C. / Wu, X. / Gileadi, C. / Ugochukwu, E. / Krysztofinska, E. / Gravel, R.A. / Oppermann, U. / Yue, W.W.
External linksJ. Biol. Chem. / PubMed:20876572
MethodsX-ray diffraction
Resolution1.95 - 2.64 Å
Structure data

PDB-2www:
Crystal Structure of Methylmalonic Acidemia Type A Protein
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

PDB-2xij:
Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2xiq:
Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin and malonyl-CoA
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-3bic:
Crystal structure of human methylmalonyl-CoA mutase
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-2PE:
NONAETHYLENE GLYCOL / precipitant*YM

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-5AD:
5'-DEOXYADENOSINE

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-B12:
COBALAMIN

ChemComp-MLC:
MALONYL-COENZYME A

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / NUCLEOTIDE-BINDING / ISOMERASE / ORGANIC ACIDURIA / VITAMIN B12 / METABOLIC DISEASE / methylmalonyl CoA mutase deficiency / Structural Genomics / Structural Genomics Consortium / SGC / Cobalamin / Cobalt / Disease mutation / Metal-binding / Mitochondrion / Transit peptide

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