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-Structure paper
Title | Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. |
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Journal, issue, pages | Mol. Cell. Biol., Vol. 30, Page 4698-4711, Year 2010 |
Publish date | Apr 16, 2008 (structure data deposition date) |
![]() | Molzan, M. / Schumacher, B. / Ottmann, C. / Baljuls, A. / Polzien, L. / Weyand, M. / Thiel, P. / Rose, R. / Rose, M. / Kuhenne, P. ...Molzan, M. / Schumacher, B. / Ottmann, C. / Baljuls, A. / Polzien, L. / Weyand, M. / Thiel, P. / Rose, R. / Rose, M. / Kuhenne, P. / Kaiser, M. / Rapp, U.R. / Kuhlmann, J. |
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Methods | X-ray diffraction |
Resolution | 1.05 - 2.4 Å |
Structure data | ![]() PDB-3cu8: ![]() PDB-3iqj: ![]() PDB-3iqu: ![]() PDB-3iqv: ![]() PDB-3nkx: ![]() PDB-3o8i: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-PPI: ![]() ChemComp-HOH: ![]() ChemComp-CL: ![]() ChemComp-FSC: ![]() ChemComp-M1T: |
Source |
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![]() | PROTEIN BINDING / SIGNALING PROTEIN / 14-3-3 / zeta / adapter protein / cRaf1 / NOONAN syndrome / LEOPARD syndrome / Phosphoprotein / SIGNAL TRANSDUCTION / Nucleus / Secreted / ATP-binding / Disease mutation / Kinase / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Proto-oncogene / Serine/threonine-protein kinase / Transferase / Zinc-finger / SIGNAL TRANSUCTION / PEPTIDE BINDING PROTEIN / Protein-Protein Complex / Protein-protein interaction / Phosphorylation |