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TitleImpaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.
Journal, issue, pagesMol. Cell. Biol., Vol. 30, Page 4698-4711, Year 2010
Publish dateApr 16, 2008 (structure data deposition date)
AuthorsMolzan, M. / Schumacher, B. / Ottmann, C. / Baljuls, A. / Polzien, L. / Weyand, M. / Thiel, P. / Rose, R. / Rose, M. / Kuhenne, P. ...Molzan, M. / Schumacher, B. / Ottmann, C. / Baljuls, A. / Polzien, L. / Weyand, M. / Thiel, P. / Rose, R. / Rose, M. / Kuhenne, P. / Kaiser, M. / Rapp, U.R. / Kuhlmann, J.
External linksMol. Cell. Biol. / PubMed:20679480
MethodsX-ray diffraction
Resolution1.05 - 2.4 Å
Structure data

PDB-3cu8:
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3iqj:
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer)
Method: X-RAY DIFFRACTION / Resolution: 1.15 Å

PDB-3iqu:
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer)
Method: X-RAY DIFFRACTION / Resolution: 1.05 Å

PDB-3iqv:
Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin
Method: X-RAY DIFFRACTION / Resolution: 1.2 Å

PDB-3nkx:
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-3o8i:
Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-PPI:
PROPANOIC ACID

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-FSC:
FUSICOCCIN

ChemComp-M1T:
6,6-dihydroxy-1-methoxyhexan-2-one

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / SIGNALING PROTEIN / 14-3-3 / zeta / adapter protein / cRaf1 / NOONAN syndrome / LEOPARD syndrome / Phosphoprotein / SIGNAL TRANSDUCTION / Nucleus / Secreted / ATP-binding / Disease mutation / Kinase / Metal-binding / Nucleotide-binding / Phorbol-ester binding / Proto-oncogene / Serine/threonine-protein kinase / Transferase / Zinc-finger / SIGNAL TRANSUCTION / PEPTIDE BINDING PROTEIN / Protein-Protein Complex / Protein-protein interaction / Phosphorylation

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