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Structure paper

TitleSpinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 17, Page 459-464, Year 2010
Publish dateSep 10, 2008 (structure data deposition date)
AuthorsRagusa, M.J. / Dancheck, B. / Critton, D.A. / Nairn, A.C. / Page, R. / Peti, W.
External linksNat. Struct. Mol. Biol. / PubMed:20305656
MethodsX-ray diffraction
Resolution1.85 - 2.2 Å
Structure data

PDB-3egg:
Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Spinophilin
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-3egh:
Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1), the PP1 binding and PDZ domains of Spinophilin and the small natural molecular toxin Nodularin-R
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3hvq:
Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MN:
Unknown entry

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
  • nodularia spumigena (bacteria)
KeywordsHYDROLASE / PP1 / Spinophilin / Serine/Threonine Phosphatase / Post Synaptic Density / Glutametergic Receptors / Carbohydrate metabolism / Cell cycle / Cell division / Glycogen metabolism / Iron / Manganese / Metal-binding / Phosphoprotein / Protein phosphatase / Actin-binding / Cell junction / Cell projection / Cytoskeleton / Developmental protein / Differentiation / Neurogenesis / Nucleus / Synapse / HYDROLASE/HYDROLASE INHIBITOR / Inhibitor / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / HYDROLASE/HYDROLASE REGULATOR / NEURABIN / Synaptosome / HYDROLASE-HYDROLASE REGULATOR COMPLEX

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