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Structure paper

TitleAtomic model for the dimeric F region of mitochondrial ATP synthase.
Journal, issue, pagesScience, Vol. 358, Issue 6365, Page 936-940, Year 2017
Publish dateNov 17, 2017
AuthorsHui Guo / Stephanie A Bueler / John L Rubinstein /
PubMed AbstractMitochondrial adenosine triphosphate (ATP) synthase produces the majority of ATP in eukaryotic cells, and its dimerization is necessary to create the inner membrane folds, or cristae, characteristic ...Mitochondrial adenosine triphosphate (ATP) synthase produces the majority of ATP in eukaryotic cells, and its dimerization is necessary to create the inner membrane folds, or cristae, characteristic of mitochondria. Proton translocation through the membrane-embedded F region turns the rotor that drives ATP synthesis in the soluble F region. Although crystal structures of the F region have illustrated how this rotation leads to ATP synthesis, understanding how proton translocation produces the rotation has been impeded by the lack of an experimental atomic model for the F region. Using cryo-electron microscopy, we determined the structure of the dimeric F complex from at a resolution of 3.6 angstroms. The structure clarifies how the protons travel through the complex, how the complex dimerizes, and how the dimers bend the membrane to produce cristae.
External linksScience / PubMed:29074581 / PubMed Central
MethodsEM (single particle)
Resolution3.6 - 7.4 Å
Structure data

EMDB-7036, PDB-6b2z:
Cryo-EM structure of the dimeric FO region of yeast mitochondrial ATP synthase
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-7037:
Cryo-EM structure of the dimeric FO region of yeast mitochondrial ATP synthase with C1 symmetry
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-7067: Cryo-EM structure of dimeric F1FO yeast mitochondrial ATP synthase with C2 symmetry
PDB-6b8h: Mosaic model of yeast mitochondrial ATP synthase monomer
Method: EM (single particle) / Resolution: 7.4 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
KeywordsMEMBRANE PROTEIN / Complex / Dimer / Mitochondrial inner membrane / Proton translocation / Proton transporter

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