PRD_000724
概要
名称: | PYOVERDIN 18-1 Fe Complex |
組成式: | C57 H84 Fe N17 O24 |
化学式量: | 1447.221 |
分子種別: | peptide-like |
ポリマー配列: | DSN, LYS, GLY, FHO, SER, DSN, GLY, LYS, FH7, SER |
非ポリマー要素: | |
BIRDクラス: | Metal Transport |
PDB中の表現: | polymer |
化合物の詳細: | PYOVERDINES ARE A GROUP OF STRUCTURALLY RELATED SIDEROPHORES PRODUCED BY FLUORESCENT PSEUDOMONAS SPECIES. PYOVERDINE IS NECESSARY FOR INFECTION IN SEVERAL DIFFERENT DISEASE MODELS. THE OCCURRENCE OF PYOVERDINE-DEFECTIVE STRAINS IN CHRONIC INFECTIONS OF PATIENTS WITH CYSTIC FIBROSIS AND THE EXTREMELY HIGH SEQUENCE DIVERSITY OF GENES INVOLVED IN PYOVERDINE SYNTHESIS AND UPTAKE INDICATE THAT PYOVERDINE PRODUCTION IS SUBJECT TO HIGH EVOLUTIONARY PRESSURE. PYOVERDINE-DEPENDENT IRON TRANSPORT IS ALSO CRUCIAL FOR BIOFILM DEVELOPMENT, FURTHER EXPANDING THE IMPORTANCE OF THESE SIDEROPHORES IN PSEUDOMONAS BIOLOGY. |
表記: | IN IRON-DEFICIENT CONDITIONS, PSEUDOMONAS AERUGINOSA SECRETES A MAJOR FLUORESCENT SIDEROPHORE NAMED PYOVERDIN (PVD), WHICH AFTER CHELATING IRON(III) IS TRANSPORTED BACK INTO THE CELL VIA ITS OUTER MEMBRANE RECEPTOR FPVA. FPVA IS A TONB-DEPENDENT TRANSPORT PROTEIN AND HAS THE ABILITY TO BIND PVD IN ITS APO- OR IRON-LOADED FORM. |
Families: | FAM_000420 |
プログラム | バージョン | 表記 |
ACDLabs | 12.01 | [N-{[(1R)-5-[(3-carboxypropanoyl)amino]-8,9-di(hydroxy-kappaO)-1,2,3,4-tetrahydropyrimido[1,2-a]quinolin-11-ium-1-yl]carbonyl}-D-seryl-6-ammonio-L-norleucylglycyl-N~5~-(formyl-kappaO)-N~5~-(hydroxy-kappaO)-L-ornithyl-L-seryl-D-seryl-N-[(3S,6R,9R)-6-{3-[(formyl-kappaO)(hydroxy-kappaO)amino]propyl}-3-(hydroxymethyl)-2,5,8-trioxo-4,7-diaza-1-azoniacyclotridecan-9-yl]glycinamidato(4-)]iron(6+) |
化合物記述子(線形表記)
種別 | プログラム | バージョン | 表記 |
SMILES | ACDLabs | 12.01 | O=C(O)CCC(=O)Nc3cc9c2cc8o[Fe+3]615(ocn(o1)CCCC7C(=O)NC(C(=O)[NH2+]CCCCC(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C4[n+]2c3NCC4)CO)CCCC[NH3+])CCCn(o5)co6)CO)CO)C(=O)N7)CO)oc8c9 |
InChI | InChI | 1.03 | InChI=1S/C57H83N17O24.Fe/c58-14-3-1-7-31(66-55(94)39(27-78)71-57(96)40-13-16-59-48-35(65-44(83)11-12-47(86)87)19-30-20-42(81)43(82)21-41(30)74(40)48)49(88)61-22-45(84)64-33(9-5-17-72(97)28-79)53(92)70-38(26-77)56(95)69-37(25-76)51(90)62-23-46(85)63-32-8-2-4-15-60-50(89)36(24-75)68-54(93)34(67-52(32)91)10-6-18-73(98)29-80;/h19-21,28-29,31-34,36-40,75-78H,1-18,22-27,58H2,(H15,59,60,61,62,63,64,65,66,67,68,69,70,71,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96);/q-2;+7/p+1 |
InChIKey | InChI | 1.03 | XVLOTPQUGADDFF-UHFFFAOYSA-O |
SMILES_CANONICAL | CACTVS | 3.370 | [NH3+]CCCC[C@@H]1NC(=O)[C@@H](CO)NC(=O)[C@@H]2CCNc3c(NC(=O)CCC(O)=O)cc4cc5O[Fe+3]6|78(|O=C[N@@](CCC[C@H](NC(=O)CNC1=O)C(=O)N[C@@H](CO)C(=O)N[C@H](CO)C(=O)NCC(=O)N[C@H]9CCCC[NH2+]C(=O)[C@H](CO)NC(=O)[C@@H](CCC[N@](O6)C=O|7)NC9=O)O8)Oc5cc4[n+]23 |
SMILES | CACTVS | 3.370 | [NH3+]CCCC[CH]1NC(=O)[CH](CO)NC(=O)[CH]2CCNc3c(NC(=O)CCC(O)=O)cc4cc5O[Fe+3]6|78(|O=C[N](CCC[CH](NC(=O)CNC1=O)C(=O)N[CH](CO)C(=O)N[CH](CO)C(=O)NCC(=O)N[CH]9CCCC[NH2+]C(=O)[CH](CO)NC(=O)[CH](CCC[N](O6)C=O|7)NC9=O)O8)Oc5cc4[n+]23 |
SMILES_CANONICAL | OpenEye OEToolkits | 1.7.6 | c1c2cc3c4cc2[n+]5c(c1NC(=O)CCC(=O)O)NCC[C@H]5C(=O)N[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H]6CCCN7C=O[Fe+3]8(O3)(O4)(O7)O=CN(O8)CCC[C@@H]9C(=O)N[C@H](C(=O)[NH2+]CCCC[C@@H](C(=O)N9)NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](NC6=O)CO)CO)CO)CCCC[NH3+])CO |
SMILES | OpenEye OEToolkits | 1.7.6 | c1c2cc3c4cc2[n+]5c(c1NC(=O)CCC(=O)O)NCCC5C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC6CCCN7C=O[Fe+3]8(O3)(O4)(O7)O=CN(O8)CCCC9C(=O)NC(C(=O)[NH2+]CCCCC(C(=O)N9)NC(=O)CNC(=O)C(NC(=O)C(NC6=O)CO)CO)CO)CCCC[NH3+])CO |