8DY5
 
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8DYG
 | | IL17A homodimer bound to Compound 7 | | Descriptor: | (5P)-2-hydroxy-5-(6-methylquinolin-5-yl)benzoic acid, Interleukin-17A | | Authors: | Argiriadi, M.A, Goedken, E.R. | | Deposit date: | 2022-08-04 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
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8DYH
 | | IL17A homodimer bound to Compound 6 | | Descriptor: | (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, Interleukin-17A | | Authors: | Argiriadi, M.A, Goedken, E.R. | | Deposit date: | 2022-08-04 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
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8DYI
 | | IL17A homodimer bound to Compound 5 | | Descriptor: | (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine, Interleukin-17A | | Authors: | Argiriadi, M.A, Goedken, E.R. | | Deposit date: | 2022-08-04 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
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8DYF
 | | IL17A homodimer bound to Compound 10 | | Descriptor: | (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid, Interleukin-17A | | Authors: | Argiriadi, M.A, Goedken, E.R. | | Deposit date: | 2022-08-04 | | Release date: | 2022-09-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep, 12, 2022
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3JVF
 | | Crystal structure of an Interleukin-17 receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Ely, L.K, Garcia, K.C. | | Deposit date: | 2009-09-16 | | Release date: | 2009-10-20 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis of receptor sharing by interleukin 17 cytokines.
Nat.Immunol., 10, 2009
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4HSA
 | | Structure of interleukin 17a in complex with il17ra receptor | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | Authors: | Liu, S. | | Deposit date: | 2012-10-29 | | Release date: | 2013-05-22 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Crystal structures of interleukin 17A and its complex with IL-17 receptor A.
Nat Commun, 4, 2013
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6HG4
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6HG9
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5NAN
 | | Crystal Structure of human IL-17AF in complex with human IL-17RA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-galactopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | Authors: | Rondeau, J.-M, Goepfert, A. | | Deposit date: | 2017-02-28 | | Release date: | 2017-09-06 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.
Sci Rep, 7, 2017
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7ZAN
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7UWL
 | | Structure of the IL-25-IL-17RB-IL-17RA ternary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-05-03 | | Release date: | 2022-07-27 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWN
 | | Structure of the IL-17A-IL-17RA-IL-17RC ternary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-05-03 | | Release date: | 2022-07-27 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWJ
 | | Structure of the homodimeric IL-25-IL-17RB binary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor B, Interleukin-25 | | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-05-03 | | Release date: | 2022-07-27 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWK
 | | Structure of the higher-order IL-25-IL-17RB complex | | Descriptor: | Interleukin-17 receptor B, Interleukin-25 | | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-05-03 | | Release date: | 2022-07-27 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWM
 | | Structure of the IL-17A-IL-17RA binary complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-05-03 | | Release date: | 2022-07-27 | | Last modified: | 2022-09-28 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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