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7KIF	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription factor Descriptor: DNA (55-MER), DNA (63-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2021-11-03 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIM	Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription factor Descriptor: DNA (45-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2021-11-03 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
7KIN	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter Descriptor: DNA (49-MER), DNA (54-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2020-10-23 Release date: 2021-04-21 Last modified: 2021-11-03 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7. Mol.Cell, 81, 2021
5W1T	X-ray crystal structure of Escherichia coli RNA polymerase and DksA complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
5X21	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and pseudouridimycin (PUM) Descriptor: (1S)-1,4-anhydro-5-[(N-carbamimidoylglycyl-N~2~-hydroxy-L-glutaminyl)amino]-5-deoxy-1-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2022-10-12 Method: X-RAY DIFFRACTION (3.323 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
5X22	Crystal structure of Thermus thermophilus transcription initiation complex with GpA and CMPcPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Zhang, Y, Ebright, R. Deposit date: 2017-01-29 Release date: 2017-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase. Cell, 169, 2017
8FTD	Structure of Escherichia coli CedA in complex with transcription initiation complex Descriptor: CHAPSO, Cell division activator CedA, DNA-directed RNA polymerase subunit alpha, ... Authors: Liu, M, Vassyliev, N, Nudler, E. Deposit date: 2023-01-11 Release date: 2024-01-10 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: General transcription factor from Escherichia coli with a distinct mechanism of action. Nat.Struct.Mol.Biol., 31, 2024
8GZH	Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: You, L.L, Shen, L.Q, Zhang, Y. Deposit date: 2022-09-27 Release date: 2023-04-19 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
8GZG	Cryo-EM structure of Synechocystis sp. PCC 6803 RPitc Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Shen, L.Q, You, L.L, Zhang, Y. Deposit date: 2022-09-27 Release date: 2023-04-19 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Cryo-EM structure of Synechocystis sp. PCC 6803 CTP-bound RPitc Proc.Natl.Acad.Sci.USA, 2023
8H3V	Cryo-EM structure of the full transcription activation complex NtcA-NtcB-TAC Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. Deposit date: 2022-10-09 Release date: 2023-10-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
8H40	Cryo-EM structure of the transcription activation complex NtcA-TAC Descriptor: DNA (125-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Han, S.J, Jiang, Y.L, You, L.L, Shen, L.Q, Wu, X.X, Yang, F, Kong, W.W, Chen, Z.P, Zhang, Y, Zhou, C.Z. Deposit date: 2022-10-09 Release date: 2023-10-04 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: DNA looping mediates cooperative transcription activation. Nat.Struct.Mol.Biol., 31, 2024
8HIH	Cryo-EM structure of Mycobacterium tuberculosis transcription initiation complex with transcription factor GlnR Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Shi, J, Xu, J.C. Deposit date: 2022-11-20 Release date: 2023-06-07 Method: ELECTRON MICROSCOPY (3.66 Å) Cite: Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
8HVR	Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wang, Y, Zheng, J. Deposit date: 2022-12-27 Release date: 2023-12-27 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces. Plos Biol., 22, 2024
7DY6	A refined cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) with SspA Descriptor: DNA (63-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lin, W. Deposit date: 2021-01-20 Release date: 2021-11-17 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: A unique binding between SspA and RNAP beta' NTH across low-GC Gram-negative bacteria facilitates SspA-mediated transcription regulation. Biochem.Biophys.Res.Commun., 583, 2021
8IGR	Cryo-EM structure of CII-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
8IGS	Cryo-EM structure of RNAP-promoter open complex at lambda promoter PRE Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zhao, M, Gao, B, Wen, A, Feng, Y, Lu, Y. Deposit date: 2023-02-21 Release date: 2023-05-17 Last modified: 2023-08-16 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of lambda CII-dependent transcription activation. Structure, 31, 2023
7F75	Cryo-EM structure of Spx-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y, Shi, J. Deposit date: 2021-06-28 Release date: 2021-10-13 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
7EH0	Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at position TSS-2, UpA RNA primer and CMPcPP Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), DNA (5'-D(*CP*C*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*AP*AP*AP*G)-3'), ... Authors: Li, L, Zhang, Y. Deposit date: 2021-03-27 Release date: 2021-07-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.808 Å) Cite: Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7EH2	Thermus thermophilus transcription initiation complex containing a template-strand pyrimidine at position TSS-2 and GpG RNA primer Descriptor: DNA (27-MER), DNA (5'-D(*CP*C*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*CP*CP*TP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Li, L, Zhang, Y. Deposit date: 2021-03-27 Release date: 2021-07-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.34 Å) Cite: Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7EH1	Thermus thermophilus transcription initiation complex containing a template-strand purine at position TSS-2, GpG RNA primer, and CMPcPP Descriptor: 1,4-BUTANEDIOL, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (27-MER), ... Authors: Li, L, Zhang, Y. Deposit date: 2021-03-27 Release date: 2021-07-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Promoter-sequence determinants and structural basis of primer-dependent transcription initiation in Escherichia coli . Proc.Natl.Acad.Sci.USA, 118, 2021
7F0R	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex Descriptor: DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2021-06-06 Release date: 2022-07-27 Last modified: 2023-02-08 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
7CKQ	The cryo-EM structure of B. subtilis BmrR transcription activation complex Descriptor: DNA (50-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Fang, C.L, Zhang, Y. Deposit date: 2020-07-18 Release date: 2020-12-16 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription. Nat Commun, 11, 2020
7C97	Cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) with SspA Descriptor: DNA (63-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lin, W, Feng, Y. Deposit date: 2020-06-05 Release date: 2020-08-12 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Structural basis for transcription inhibition by E. coli SspA Nucleic Acids Res., 2020
7CHW	Cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) Descriptor: DNA (63-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lin, W, Feng, Y. Deposit date: 2020-07-06 Release date: 2020-08-12 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Structural basis for transcription inhibition by E. coli SspA Nucleic Acids Res., 2020
6B6H	The cryo-EM structure of a bacterial class I transcription activation complex Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Liu, B, Hong, C, Huang, R, Yu, Z, Steitz, T.A. Deposit date: 2017-10-02 Release date: 2017-11-15 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of bacterial transcription activation. Science, 358, 2017

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