PDB: 39 resultsInfo pagesStatus searchChemie searchBIRD

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7K0Y	Cryo-EM structure of activated-form DNA-PK (complex VI) Descriptor: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... Authors: Chen, X, Gellert, M, Yang, W. Deposit date: 2020-09-06 Release date: 2021-01-06 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
7K1J	CryoEM structure of inactivated-form DNA-PK (Complex III) Descriptor: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... Authors: Chen, X, Gellert, M, Yang, W. Deposit date: 2020-09-07 Release date: 2021-01-06 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
7K1N	CryoEM structure of inactivated-form DNA-PK (Complex V) Descriptor: DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... Authors: Chen, X, Gellert, M, Yang, W. Deposit date: 2020-09-08 Release date: 2021-01-06 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
7K1K	CryoEM structure of inactivated-form DNA-PK (Complex IV) Descriptor: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... Authors: Chen, X, Gellert, M, Yang, W. Deposit date: 2020-09-07 Release date: 2021-01-06 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
7LT3	NHEJ Long-range synaptic complex Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... Authors: He, Y, Chen, S. Deposit date: 2021-02-18 Release date: 2021-04-14 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structural basis of long-range to short-range synaptic transition in NHEJ. Nature, 593, 2021
7Z88	DNA-PK in the intermediate state Descriptor: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... Authors: Liang, S, Blundell, T.L. Deposit date: 2022-03-16 Release date: 2023-01-18 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Human DNA-dependent protein kinase activation mechanism. Nat.Struct.Mol.Biol., 30, 2023
7Z87	DNA-PK in the active state Descriptor: (~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol, DNA (26-MER), DNA-dependent protein kinase catalytic subunit, ... Authors: Liang, S, Blundell, T.L. Deposit date: 2022-03-16 Release date: 2023-01-18 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (2.91 Å) Cite: Human DNA-dependent protein kinase activation mechanism. Nat.Struct.Mol.Biol., 30, 2023
7Z6O	X-Ray studies of Ku70/80 reveal the binding site for IP6 Descriptor: DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... Authors: Varela, P.F, Charbonnier, J.B. Deposit date: 2022-03-14 Release date: 2023-08-30 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3.7 Å) Cite: Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
8AG4	Vaccinia C16 protein bound to Ku70/Ku80 Descriptor: Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 Authors: Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. Deposit date: 2022-07-19 Release date: 2022-11-09 Last modified: 2022-11-30 Method: ELECTRON MICROSCOPY (2.46 Å) Cite: Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
8AG5	Vaccinia C16 protein bound to Ku70/Ku80 Descriptor: Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 Authors: Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. Deposit date: 2022-07-19 Release date: 2022-11-09 Last modified: 2022-11-30 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
7ZT6	Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate Descriptor: INOSITOL HEXAKISPHOSPHATE, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 Authors: Kefala Stavridi, A, Chaplin, A.K, Blundell, T.L. Deposit date: 2022-05-09 Release date: 2023-05-17 Last modified: 2023-12-06 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
7ZVT	CryoEM structure of Ku heterodimer bound to DNA Descriptor: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... Authors: Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. Deposit date: 2022-05-17 Release date: 2023-05-24 Last modified: 2023-12-06 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
7ZWA	CryoEM structure of Ku heterodimer bound to DNA and PAXX Descriptor: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ... Authors: Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. Deposit date: 2022-05-19 Release date: 2023-05-31 Last modified: 2023-06-14 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
7ZYG	CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF Descriptor: DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ... Authors: Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. Deposit date: 2022-05-24 Release date: 2023-06-07 Last modified: 2023-06-14 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023

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