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2V22	REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE Authors: Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. Deposit date: 2007-05-31 Release date: 2008-01-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors Chembiochem, 7, 2006
2WHB	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design Descriptor: ARG-ARG-L3O-PFF, CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2 Authors: Kontopidis, G, Andrews, M.J, McInnes, C, Plater, A, Innes, L, Renachowski, S, Cowan, A, Fischer, P.M. Deposit date: 2009-05-03 Release date: 2009-06-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Truncation and optimisation of peptide inhibitors of cyclin-dependent kinase 2-cyclin a through structure-guided design. Chemmedchem, 4, 2009
2WMA	Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A Descriptor: CELL DIVISION PROTEIN KINASE 2, CYCLIC RKLFN-NH2, CYCLIN-A2 Authors: Robertson, G.F, Endicott, J.A, Noble, M.E.M, McDonnell, J.M. Deposit date: 2009-06-30 Release date: 2010-09-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A To be Published
2W99	Crystal Structure of CDK4 in complex with a D-type cyclin Descriptor: CELL DIVISION PROTEIN KINASE 4, G1/S-SPECIFIC CYCLIN-D1 Authors: Day, P.J, Cleasby, A, Tickle, I.J, Reilly, M.O, Coyle, J.E, Holding, F.P, McMenamin, R.L, Yon, J, Chopra, R, Lengauer, C, Jhoti, H. Deposit date: 2009-01-22 Release date: 2009-03-10 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106, 2009
2X1N	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design Descriptor: 2-METHYL-N-[(1Z)-3-NITROCYCLOHEXA-2,4-DIEN-1-YLIDENE]-4,5-DIHYDRO[1,3]THIAZOLO[4,5-H]QUINAZOLIN-8-AMINE, ACE-LEU-ASN-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ... Authors: Kontopidis, G, Andrews, M.J, McInnes, C, Plater, A, Innes, L, Renachowski, S, Cowan, A, Fischer, P.M, McIntyre, N.A, Griffiths, G, Barnett, A.L, Slawin, A.M.Z, Jackson, W, Thomas, M, Zheleva, D.I, Wang, S, Blake, D.G, Westwood, N.J. Deposit date: 2009-12-31 Release date: 2010-02-16 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-Aryl-4,5-Dihydrothiazolo[4,5-H]Quinazolin-8-Amines as Ring-Constrained 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Cyclin-Dependent Kinase Inhibitors. J.Med.Chem., 53, 2010

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