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5YQO	Crystal structure of Sirt2 in complex with selective inhibitor L5C Descriptor: N-[4-[[3-[2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanoylamino]phenyl]methoxy]phenyl]-1-methyl-pyrazole-4-carboxamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION Authors: Wang, H, Yu, Y, Li, G, Chen, Q. Deposit date: 2017-11-07 Release date: 2018-10-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.483 Å) Cite: X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5YQM	Crystal structure of Sirt2 in complex with selective inhibitor A29 Descriptor: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-(4-phenylsulfanylphenyl)ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Wang, H, Yu, Y, Li, G, chen, Q. Deposit date: 2017-11-07 Release date: 2018-10-17 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.735 Å) Cite: X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
5YQL	Crystal structure of Sirt2 in complex with selective inhibitor A2I Descriptor: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[3-(phenoxymethyl)phenyl]ethanamide, BETA-MERCAPTOETHANOL, NAD-dependent protein deacetylase sirtuin-2, ... Authors: Wang, H, Yu, Y, Li, G, Chen, Q. Deposit date: 2017-11-07 Release date: 2018-10-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.601 Å) Cite: X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem, 155, 2018
8CCW	Crystal structure of human Sirt3 in complex with an acetylated HIV1 Tat-46-54 substrate peptide Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Protein Tat, ... Authors: Adolph, R.S, Steegborn, C. Deposit date: 2023-01-27 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life, 13, 2023
5Z94	Crystal Structure of SIRT3 in complex with H3K4bhb peptide Descriptor: CITRIC ACID, GLYCEROL, Gene for histone H3 (germline gene), ... Authors: Zhang, X, Li, H. Deposit date: 2018-02-02 Release date: 2019-02-06 Method: X-RAY DIFFRACTION (1.899 Å) Cite: Crystal Structure of SIRT3 in complex with H3K4bhb peptide To Be Published
5ZGC	Crystal Structure of SIRT3 in complex with H4K16bhb peptide Descriptor: Histone H4K16bhb peptide, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... Authors: Li, H, Zhang, X. Deposit date: 2018-03-08 Release date: 2019-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal Structure of SIRT3 in complex with H4K16bhb peptide To be published
8CNO	Improved complex structure of human Sirtuin 6 with its inhibitor cis-resveratrol Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: You, W, Steegborn, C. Deposit date: 2023-02-23 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
8CNM	Human Sirt6 in complex with the inhibitor S6020 and ADP-ribose Descriptor: 1,2-ETHANEDIOL, 4-azanyl-~{N}-(4-oxidanylcyclohexyl)benzenesulfonamide, CHLORIDE ION, ... Authors: You, W, Steegborn, C. Deposit date: 2023-02-23 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
5Z93	Crystal Structure of SIRT3 in complex with H3K9bhb peptide Descriptor: Gene for histone H3 (germline gene), NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... Authors: Zhang, X, Li, H. Deposit date: 2018-02-02 Release date: 2019-02-06 Method: X-RAY DIFFRACTION (1.945 Å) Cite: Crystal Structure of SIRT3 in complex with H3K9bhb peptide To Be Published
6ACL	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2AK95 Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.92 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2AK95 To Be Published
6ACP	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H4K91 Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H4K91 To Be Published
6ACE	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H3K122 Descriptor: GLYCEROL, NAD-dependent protein deacylase sirtuin-5, mitochondrial, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.98 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H3K122 To Be Published
6ACO	histone lysine desuccinylase Sirt5 in complex with succinyl peptide H2BK120 Descriptor: CHLORIDE ION, GLYCEROL, NAD-dependent protein deacylase sirtuin-5, ... Authors: Hang, T.R, Chen, W.B. Deposit date: 2018-07-26 Release date: 2019-07-24 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.71 Å) Cite: complex structure of histone lysine desuccinylase Sirt5 with succinyl peptide H2BK120 To Be Published
2HJH	Crystal Structure of the Sir2 deacetylase Descriptor: (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE, NAD-dependent histone deacetylase SIR2, NICOTINAMIDE, ... Authors: Hall, B.E, Ellenberger, T.E. Deposit date: 2006-06-30 Release date: 2008-04-08 Last modified: 2017-10-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site To be Published
4IAO	Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4 Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent histone deacetylase SIR2, Regulatory protein SIR4, ... Authors: Hsu, H.C, Wang, C.L, Wang, M, Yang, N, Chen, Z, Sternglanz, R, Xu, R.M. Deposit date: 2012-12-07 Release date: 2012-12-26 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.901 Å) Cite: Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding Genes Dev., 27, 2013
8BBK	Crystal structure of human Sirt3 in complex with a fragment of the human AROS protein Descriptor: Active regulator of SIRT1, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, ... Authors: Steegborn, C, Weiss, S. Deposit date: 2022-10-13 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein. Int J Mol Sci, 23, 2022
8F86	SIRT6 bound to an H3K9Ac nucleosome Descriptor: DNA (148-MER), Histone H2A type 1, Histone H2B, ... Authors: Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. Deposit date: 2022-11-21 Release date: 2023-04-05 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation. J.Am.Chem.Soc., 145, 2023
8G57	Structure of nucleosome-bound Sirtuin 6 deacetylase Descriptor: DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ... Authors: Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P. Deposit date: 2023-02-11 Release date: 2023-04-26 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: Cryo-EM structure of the human Sirtuin 6-nucleosome complex. Sci Adv, 9, 2023
8OF4	Nucleosome Bound human SIRT6 (Composite) Descriptor: DNA (145-MER), Histone H2A type 1, Histone H2B, ... Authors: Smirnova, E, Bignon, E, Schultz, P, Papai, G, Ben-Shem, A. Deposit date: 2023-03-13 Release date: 2023-08-09 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Binding to nucleosome poises human SIRT6 for histone H3 deacetylation. Elife, 12, 2024
8CCZ	Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Protein Tat, ... Authors: Adolph, R.S, Steegborn, C. Deposit date: 2023-01-28 Release date: 2023-05-10 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life, 13, 2023

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